| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87 |
| Entrez GeneID | 2917 |
| clone | 7G8D3 |
| WB Predicted band size | 102.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GRM7 (AA: 454-590) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于GRM7抗体的3篇参考文献概览：
1. **文献名称**：*GRM7 Expression in the Hippocampus of Patients with Temporal Lobe Epilepsy*
**作者**：Smith A, et al.
**摘要**：该研究利用GRM7特异性抗体通过免疫组化技术，发现癫痫患者海马组织中GRM7蛋白表达显著下调，提示其可能与神经元过度兴奋相关。
2. **文献名称**：*Antibody-Based Detection of mGluR7 in Mouse Brain Synaptic Membranes*
**作者**：Chen L, et al.
**摘要**：通过Western blot和免疫电镜实验验证了GRM7抗体的特异性，揭示了该受体在小鼠突触前膜富集分布，支持其在神经递质释放调控中的作用。
3. **文献名称**：*GRM7 Variants and Autism Spectrum Disorder: A Protein Expression Study*
**作者**：Wang Y, et al.
**摘要**：研究采用GRM7抗体分析自闭症患者皮质样本，发现特定基因突变伴随GRM7蛋白异常截短，为自闭症的分子机制提供新证据。
(注：以上文献为示例性内容，实际引用需查询具体数据库获取真实研究。)
The GRM7 antibody targets the metabotropic glutamate receptor 7 (mGlu7), a Class C G protein-coupled receptor (GPCR) primarily expressed in the central nervous system. As one of eight mGlu receptors, GRM7 regulates synaptic transmission and plasticity by modulating neurotransmitter release, particularly glutamate and GABA. It is predominantly localized presynaptically, acting as an autoreceptor to inhibit glutamate release or heteroreceptor to influence other neurotransmitters. GRM7 signaling involves coupling with Gαi/o proteins, reducing cAMP levels, and regulating ion channel activity.
Research using GRM7 antibodies has linked this receptor to neurological and psychiatric disorders, including anxiety, depression, autism spectrum disorders, and epilepsy. Antibodies against GRM7 (polyclonal or monoclonal) are critical tools for detecting receptor expression via Western blot (WB), immunohistochemistry (IHC), or immunocytochemistry (ICC). They also aid in studying GRM7's role in synaptic function, behavior, and disease mechanisms.
Recent studies highlight GRM7 as a therapeutic target, with agonists/antagonists explored for neuropsychiatric treatments. Variants in the GRM7 gene are associated with altered receptor function in neurodevelopmental conditions. However, antibody specificity remains a challenge due to homology among mGlu receptors, requiring rigorous validation via knockout controls. Overall, GRM7 antibodies are indispensable for advancing understanding of glutamate signaling and its implications in brain disorders.
×
