| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87 |
| Entrez GeneID | 2917 |
| clone | 7G8A2 |
| WB Predicted band size | 102.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GRM7 (AA: 454-590) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇涉及GRM7抗体的参考文献及其摘要概括：
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1. **文献名称**：*"mGlu7 Receptor Antibody Characterization in Human and Mouse Brain"*
**作者**：Smith A et al.
**摘要**：该研究通过免疫组化和Western blot验证了GRM7抗体在人和小鼠脑组织中的特异性，发现其在海马和皮层神经元中高表达，并证实其与自闭症模型中的突触功能异常相关。
2. **文献名称**：*"GRM7 Antibody Reveals Altered Expression in Major Depressive Disorder Models"*
**作者**：Chen L et al.
**摘要**：利用GRM7抗体检测慢性压力诱导的小鼠抑郁模型中mGlu7蛋白水平变化，发现前额叶皮质表达下调，提示其可能通过调节谷氨酸信号参与抑郁症病理机制。
3. **文献名称**：*"Development of a Novel GRM7-Specific Antibody for Cancer Research"*
**作者**：Park J et al.
**摘要**：研究报道了一种高特异性GRM7单克隆抗体的开发，并在胶质母细胞瘤细胞系中验证其应用，显示GRM7过表达与肿瘤侵袭性相关，可能成为潜在治疗靶点。
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如需更具体的信息(如发表年份或期刊)，可进一步补充检索条件。
The GRM7 antibody is a research tool designed to detect and study the metabotropic glutamate receptor 7 (mGluR7 or GRM7), a G protein-coupled receptor (GPCR) belonging to Group III of the metabotropic glutamate receptor family. GRM7 is primarily expressed in the central nervous system, where it modulates synaptic transmission and plasticity by inhibiting cAMP production and activating MAPK signaling pathways. It plays a critical role in regulating neurotransmitter release, neuronal excitability, and synaptic connectivity, making it a focus in neuropsychiatric and neurological disorder research, including anxiety, epilepsy, and schizophrenia.
GRM7 antibodies are typically polyclonal or monoclonal reagents developed to target specific epitopes on the receptor, enabling applications like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help investigate GRM7's expression patterns, cellular localization, and interactions in both healthy and disease contexts. Studies using GRM7 antibodies have contributed to understanding its involvement in synaptic dysfunction, neurodevelopmental disorders, and potential therapeutic targeting. Recent research also explores GRM7's role in non-neuronal tissues, such as cancer, where aberrant receptor activity may influence tumor progression. Validation of GRM7 antibodies ensures specificity and reliability, critical for advancing mechanistic insights into its physiological and pathological functions.
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