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Mouse Monoclonal PTPN14 Antibody

  • 中文名： PTPN14抗体
  • 别    名： PEZ; PTP36
货号: IPD31049
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/200 - 1/1000 Human,Mouse,Rat
ICC 1/200 - 1/1000 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesPEZ; PTP36
Entrez GeneID5784
clone2C12E3
WB Predicted band size135.3kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PTPN14 (AA: 896-1169) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是3-4条关于PTPN14抗体的参考文献示例(内容为虚构，仅用于格式参考)：

1. **文献名称**：*PTPN14 regulates YAP activity through Hippo signaling in cell proliferation*

**作者**：Huang X, et al.

**摘要**：研究揭示了PTPN14通过磷酸化YAP蛋白调控Hippo信号通路，抑制肿瘤细胞增殖，实验中采用PTPN14抗体进行免疫共沉淀验证相互作用。

2. **文献名称**：*PTPN14 suppresses breast cancer metastasis by modulating EGFR endocytosis*

**作者**：Wilson JR, et al.

**摘要**：该文献发现PTPN14通过调控EGFR内吞作用抑制乳腺癌转移，Western blot和免疫荧光实验中使用了特异性PTPN14抗体证实其表达下调与患者预后不良相关。

3. **文献名称**：*PTPN14 interacts with VEGFR2 to coordinate embryonic angiogenesis*

**作者**：Belle L, et al.

**摘要**：研究通过免疫组织化学(使用PTPN14抗体)和基因敲除模型，证明PTPN14与VEGFR2结合调控血管生成，缺陷导致小鼠胚胎发育异常。

4. **文献名称**：*PTPN14 as a potential biomarker in colorectal cancer*

**作者**：Zhang Y, et al.

**摘要**：通过免疫组化分析(基于PTPN14抗体)，发现PTPN14在结直肠癌组织中低表达，且与肿瘤侵袭性和患者生存率显著相关。

(注：以上文献为示例，实际引用需查询真实数据库如PubMed。)

背景信息

The PTPN14 antibody targets the protein tyrosine phosphatase non-receptor type 14 (PTPN14), a member of the non-receptor protein tyrosine phosphatase (PTP) family. PTPN14. encoded by the PTPN14 gene, regulates cellular signaling by dephosphorylating tyrosine residues on target proteins. It plays critical roles in cell adhesion, polarity, and proliferation, primarily through interactions with key pathways like the Hippo-YAP signaling axis. PTPN14 binds to and inhibits YAP (Yes-associated protein), a transcriptional coactivator involved in organ size control and tumorigenesis, thereby suppressing oncogenic growth. Structurally, PTPN14 contains a FERM domain for membrane localization and a catalytic phosphatase domain. Dysregulation of PTPN14 has been implicated in cancers, including breast, colorectal, and squamous cell carcinomas, where it may act as a tumor suppressor or context-dependent oncogene. Antibodies against PTPN14 are widely used in research to study its expression, subcellular localization, and molecular interactions via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These tools help elucidate its dual roles in development and disease, particularly its interplay with cell junction proteins (e.g., VE-cadherin, β-catenin) and its potential as a therapeutic target in cancer.

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