Mouse Monoclonal PTPN14 Antibody

The PTPN14 antibody targets the protein tyrosine phosphatase non-receptor type 14 (PTPN14), a member of the non-receptor protein tyrosine phosphatase (PTP) family. PTPN14. encoded by the PTPN14 gene, regulates cellular signaling by dephosphorylating tyrosine residues on target proteins. It plays critical roles in cell adhesion, polarity, and proliferation, primarily through interactions with key pathways like the Hippo-YAP signaling axis. PTPN14 binds to and inhibits YAP (Yes-associated protein), a transcriptional coactivator involved in organ size control and tumorigenesis, thereby suppressing oncogenic growth. Structurally, PTPN14 contains a FERM domain for membrane localization and a catalytic phosphatase domain. Dysregulation of PTPN14 has been implicated in cancers, including breast, colorectal, and squamous cell carcinomas, where it may act as a tumor suppressor or context-dependent oncogene. Antibodies against PTPN14 are widely used in research to study its expression, subcellular localization, and molecular interactions via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These tools help elucidate its dual roles in development and disease, particularly its interplay with cell junction proteins (e.g., VE-cadherin, β-catenin) and its potential as a therapeutic target in cancer.