| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 5AS1, Olfactory receptor OR11-168, OR5AS1 |
| Entrez GeneID | 219447 |
| WB Predicted band size | 36.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR5AS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-272 amino acids from the C-terminal region of human OR5AS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于POMC抗体的参考文献示例(内容为虚构概括，仅作格式参考)：
1. **文献名称**: "Immunohistochemical localization of POMC-derived peptides in human hypothalamus"
**作者**: Smith A, et al.
**摘要**: 通过新型POMC抗体的免疫组化分析，揭示了人类下丘脑中α-MSH和β-内啡肽的分布模式，证实该抗体对POMC裂解产物的高特异性。
2. **文献名称**: "Development and validation of a monoclonal POMC antibody for obesity research"
**作者**: Lee J, et al.
**摘要**: 研究团队开发了一种针对POMC N端的单克隆抗体，经Western blot和免疫荧光验证，成功应用于肥胖模型小鼠的POMC神经元定量分析。
3. **文献名称**: "POMC antibody cross-reactivity analysis across vertebrate species"
**作者**: Gonzalez R, et al.
**摘要**: 系统性评估了市售POMC抗体在哺乳动物、鸟类中的交叉反应性，发现Clone AB123在人类和小鼠样本中具有最佳特异性，为跨物种比较研究提供依据。
注：以上文献信息为基于领域常见研究方向的模拟概括，实际文献需通过PubMed或Web of Science等数据库检索确认。
The pro-opiomelanocortin (POMC) antibody is a critical tool in biomedical research and diagnostics, targeting the POMC precursor protein. POMC is a polypeptide hormone precursor expressed primarily in the hypothalamus, pituitary gland, and skin. It undergoes tissue-specific proteolytic cleavage to yield biologically active peptides, including adrenocorticotropic hormone (ACTH), β-endorphin, and α-melanocyte-stimulating hormone (α-MSH). These peptides regulate diverse physiological processes, such as stress response, energy homeostasis, pain modulation, and pigmentation.
POMC antibodies are widely used to detect and quantify POMC-derived peptides in experimental and clinical settings. In research, they facilitate studies on endocrine signaling, metabolic disorders (e.g., obesity), and adrenal dysfunction. Clinically, they aid in diagnosing conditions like Cushing’s syndrome (linked to ACTH overproduction) and neuroendocrine tumors. Antibodies targeting specific regions of POMC (e.g., ACTH or β-endorphin epitopes) enable precise detection in immunoassays, immunohistochemistry, or Western blotting.
The development of high-specificity POMC antibodies is challenging due to the protein’s post-translational processing and homology across species. Validation for cross-reactivity and sensitivity is crucial, particularly in distinguishing intact POMC from its fragments. Recent advancements in monoclonal antibody technology have improved reproducibility, supporting both mechanistic studies and therapeutic exploration, such as targeting POMC pathways for obesity treatment.
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