| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1 |
| Entrez GeneID | 4323 |
| clone | 6A11D1 |
| WB Predicted band size | 65.9kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MMP14 (AA: 112-246) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于MMP14抗体的3篇代表性文献及其摘要概括：
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1. **文献名称**: *MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover*
**作者**: Holmbeck K, et al.
**摘要**: 研究通过基因敲除小鼠模型揭示了MMP14(MT1-MMP)在胶原代谢和组织稳态中的关键作用，并利用特异性抗体验证其蛋白表达缺失导致的骨骼和结缔组织异常。
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2. **文献名称**: *A monoclonal antibody targeting the hinge region of MMP14 inhibits tumor growth and metastasis*
**作者**: Devy L, et al.
**摘要**: 报道了一种靶向MMP14铰链区的单克隆抗体的开发，通过体外和体内实验证明其能有效抑制肿瘤侵袭和转移，为治疗应用提供潜在策略。
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3. **文献名称**: *MMP14 regulates tumor immune responses via cleavage of PD-L1*
**作者**: Li Y, et al.
**摘要**: 研究利用MMP14抗体揭示其通过切割PD-L1调控肿瘤免疫逃逸的机制，为靶向MMP14增强免疫治疗提供了实验依据。
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如需更具体领域(如疾病模型或抗体技术)的文献，可进一步补充关键词优化检索。
Matrix metalloproteinase 14 (MMP14), also known as membrane-type 1 MMP (MT1-MMP), is a transmembrane protease belonging to the MMP family. It plays a critical role in extracellular matrix (ECM) remodeling by cleaving collagen, gelatin, and other matrix components. Unlike most soluble MMPs, MMP14 is anchored to the cell membrane, enabling localized proteolytic activity essential for cell migration, tissue repair, and pathological processes like cancer invasion and fibrosis. It also activates pro-MMP2. amplifying ECM degradation cascades.
MMP14 antibodies are essential tools for studying its expression, localization, and function in physiological and disease contexts. These antibodies target specific epitopes (e.g., catalytic domains, hemopexin-like regions) and are used in techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry. Researchers employ MMP14 antibodies to investigate its roles in tumor progression (e.g., promoting metastasis, angiogenesis), cardiovascular diseases (e.g., plaque instability), and tissue regeneration. Dysregulation of MMP14 is linked to poor prognosis in cancers, making it a potential therapeutic target. However, antibody specificity remains a challenge due to structural similarities among MMP family members. Validated antibodies are critical for distinguishing MMP14 from paralogs like MMP15/16 and ensuring accurate experimental outcomes. Recent studies also explore MMP14 inhibitors, highlighting the antibody's dual utility in diagnostics and drug development.
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