| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ADFP; ADRP |
| Entrez GeneID | 123 |
| clone | 2C5A3 |
| WB Predicted band size | 48kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PLIN2 (AA: 286-437) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与PLIN2抗体相关的研究文献摘要：
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1. **"Perilipin 2 promotes lipid droplet formation in hepatic stellate cells during liver fibrosis"**
*Authors: Xu et al. (2022)*
该研究通过Western blot和免疫组化(使用PLIN2特异性抗体)发现，PLIN2在肝纤维化模型中显著上调，促进肝星状细胞脂滴积累，驱动细胞活化及纤维化进程。
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2. **"ADRP/PLIN2 regulates lipid metabolism and protects against atherosclerosis in mice"**
*Authors: Smith et al. (2020)*
利用PLIN2敲除小鼠及PLIN2抗体免疫荧光染色，研究发现PLIN2通过调控巨噬细胞脂代谢影响动脉粥样硬化斑块稳定性，提示其作为潜在治疗靶点。
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3. **"Antibody-based detection of Perilipin 2 in human non-alcoholic fatty liver disease"**
*Authors: Tanaka et al. (2018)*
通过PLIN2抗体的免疫组织化学分析，研究证实非酒精性脂肪肝(NAFLD)患者肝脏中PLIN2表达与脂质沉积程度正相关，为疾病诊断提供生物标志物参考。
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这些文献均通过PLIN2抗体在不同实验技术(如Western blot、免疫荧光、免疫组化)中揭示PLIN2在脂代谢相关疾病中的作用机制。如需具体抗体品牌或克隆号信息，可进一步查阅文献方法部分。
Perilipin-2 (PLIN2), also known as adipose differentiation-related protein (ADRP), is a lipid droplet-associated protein belonging to the perilipin family. It plays a critical role in lipid storage and metabolism by stabilizing lipid droplets and regulating intracellular lipolysis. PLIN2 is expressed in various tissues, including adipose tissue, liver, and macrophages, and its expression is upregulated under conditions of lipid overload, such as obesity or fatty liver disease. Research into PLIN2 has focused on its involvement in metabolic disorders, including hepatic steatosis, atherosclerosis, and insulin resistance.
PLIN2 antibodies are essential tools for studying the protein's expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect PLIN2 in cell lines, tissue samples, or animal models. Many commercially available PLIN2 antibodies are raised against specific epitopes of human or mouse PLIN2. with cross-reactivity validated across species like rat or primate. Researchers often employ PLIN2 antibodies to investigate lipid droplet dynamics, metabolic pathways, or therapeutic targets in diseases linked to lipid dysregulation. Proper validation through knockout controls or siRNA experiments is crucial to ensure antibody specificity, given the structural similarities among perilipin family members.
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