首页 / 产品 / 抗体 / 一抗

Mouse Monoclonal ONECUT3 Antibody

  • 中文名： ONECUT3抗体
  • 别    名： OC3
货号: IPD30533
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/200 - 1/1000 Human,Mouse,Rat
ICC 1/200 - 1/1000 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesCoiled-coil domain-containing protein 89 {ECO:0000312|RGD:1305335}, Bc8 orange-interacting protein, Ccdc89 {ECO:0000312|EMBL:AAI670631, ECO:0000312|RGD:1305335}
Entrez GeneID293107
WB Predicted band size43.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis Rat Ccdc89 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-145 amino acids from the Central region of rat Ccdc89.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于ONECUT3抗体的3篇参考文献及其摘要概括：

---

1. **文献名称**: "ONECUT3 is a regulator of neuroendocrine differentiation in prostate cancer"

**作者**: Smith J, et al.

**摘要**: 本研究利用ONECUT3特异性抗体，通过免疫组化和Western blot技术，揭示了ONECUT3在前列腺癌神经内分泌分化中的关键作用，并发现其高表达与患者预后不良相关。

---

2. **文献名称**: "Development and validation of a monoclonal antibody specific for human ONECUT3 transcription factor"

**作者**: Lee S, et al.

**摘要**: 文章描述了针对人源ONECUT3蛋白的单克隆抗体的开发与验证，通过免疫沉淀和免疫荧光实验证实了抗体的高特异性，为后续功能研究提供了可靠工具。

---

3. **文献名称**: "ONECUT3 promotes pancreatic cancer progression by transcriptional activation of oncogenic pathways"

**作者**: Zhang Y, et al.

**摘要**: 研究使用ONECUT3抗体进行ChIP-seq分析，发现ONECUT3通过调控多个致癌基因(如MYC和MET)的转录，驱动胰腺癌的侵袭和转移。

---

注：以上文献为示例，实际引用时建议通过PubMed或Google Scholar检索最新研究以确保准确性。

背景信息

The ONECUT3 antibody targets the ONECUT3 protein (also known as HNF6γ or OC-3), a member of the ONECUT transcription factor family characterized by a single cut-like DNA-binding domain. ONECUT3 plays critical roles in embryonic development, tissue differentiation, and metabolic regulation, particularly in organs like the liver, pancreas, and nervous system. It regulates gene networks involved in cell fate determination, organogenesis, and maintenance of specialized cellular functions. Antibodies against ONECUT3 are widely used in research to study its expression patterns, subcellular localization, and functional interactions via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These tools have revealed ONECUT3's involvement in diseases, including cancers (e.g., hepatocellular carcinoma, neuroendocrine tumors) where its dysregulation correlates with tumor progression. Most ONECUT3 antibodies are raised in rabbits or mice, often targeting specific epitopes within its C-terminal or N-terminal regions. Validation typically includes knockout controls to confirm specificity. As ONECUT3's role in cellular plasticity and disease mechanisms gains attention, its antibodies remain vital for exploring developmental biology, metabolic disorders, and oncogenic pathways.

客户数据及评论

折叠内容

大包装询价

×