| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | TRAP; SPENCDI |
| Entrez GeneID | 54 |
| clone | 5C5E7 |
| WB Predicted band size | 36.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ACP5 (AA: 221-325) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ACP5抗体的3篇参考文献示例(文献信息为虚构，仅供格式参考)：
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1. **文献名称**: *ACP5 expression in osteoclasts: a biomarker for bone metastasis in breast cancer*
**作者**: Smith J, et al.
**摘要**: 研究通过免疫组化分析ACP5抗体在乳腺癌骨转移组织中的表达，发现ACP5在破骨细胞中显著上调，与骨破坏程度和患者预后不良相关，提示其作为转移性骨病的潜在标志物。
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2. **文献名称**: *TRAP/ACP5 antibody-based detection in rheumatoid arthritis synovial tissue*
**作者**: Lee H, et al.
**摘要**: 利用特异性ACP5抗体检测类风湿关节炎滑膜组织中的TRAP活性，发现其表达与炎症细胞浸润和关节损伤程度相关，为疾病进展提供了分子机制依据。
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3. **文献名称**: *Development of a novel monoclonal ACP5 antibody for functional studies in osteoclastogenesis*
**作者**: Tanaka K, et al.
**摘要**: 报道了一种新型抗人ACP5单克隆抗体的开发，验证其在体外破骨细胞分化模型中的应用，证实ACP5在骨吸收过程中的关键作用，并用于靶向治疗研究。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“ACP5 antibody”或“TRAP antibody”获取近期研究。
ACP5. also known as tartrate-resistant acid phosphatase (TRAP), is a metalloenzyme encoded by the ACP5 gene. It belongs to the acid phosphatase family and is characterized by its resistance to inhibition by tartrate. Structurally, it contains two iron-binding sites and a manganese-binding site critical for its enzymatic activity. ACP5 is primarily expressed in osteoclasts, immune cells (macrophages, dendritic cells), and certain cancer cells. In bone biology, ACP5 plays a key role in osteoclast-mediated bone resorption, facilitating the degradation of bone matrix during remodeling. Dysregulation of ACP5 is linked to pathological conditions, including osteoporosis, rheumatoid arthritis, and bone metastases in cancers.
ACP5 antibodies are immunological tools used to detect and quantify this enzyme in research and diagnostics. They enable the study of osteoclast differentiation, bone metabolism disorders, and tumor microenvironment interactions. In cancer research, ACP5 antibodies help investigate its role in promoting tumor cell invasion and metastasis. Clinically, elevated serum ACP5 levels, detected via antibody-based assays, serve as a biomarker for bone turnover diseases. Recent studies also explore ACP5's involvement in immune regulation, particularly in dendritic cell function and inflammatory responses. These antibodies are pivotal in elucidating ACP5's dual roles in physiological remodeling and disease progression, with potential therapeutic implications.
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