| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CD146; MUC18 |
| Entrez GeneID | 4162 |
| clone | 6C3E6 |
| WB Predicted band size | 71.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MCAM (AA: 84-189) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于MCAM抗体的3篇参考文献示例(注：具体文献信息可能需要通过学术数据库进一步验证)：
1. **"MCAM/CD146 as a multifunctional regulator of tumor progression"**
*作者：Johnson K.S. et al.*
**摘要**：探讨MCAM抗体在抑制黑色素瘤转移中的作用，证明其通过阻断细胞迁移信号通路降低肿瘤侵袭性。
2. **"Therapeutic targeting of CD146/MCAM in angiogenesis-related diseases"**
*作者：Li Y. et al.*
**摘要**：研究MCAM中和抗体在抑制病理性血管生成中的应用，显示其在动物模型中减少视网膜病变和肿瘤血管密度。
3. **"MCAM antibody-based imaging probes for early detection of triple-negative breast cancer"**
*作者：Wang H. & Zheng L.*
**摘要**：开发靶向MCAM的荧光标记抗体，验证其在三阴性乳腺癌小鼠模型中高特异性成像和早期诊断潜力。
(如需具体文献，建议通过PubMed或Google Scholar以“MCAM antibody”、“CD146 therapeutic”等关键词检索最新研究。)
MCAM (Melanoma Cell Adhesion Molecule), also known as CD146. is a cell surface glycoprotein belonging to the immunoglobulin superfamily. Initially identified in melanoma, it is expressed in various cell types, including endothelial cells, smooth muscle cells, and activated T-cells. MCAM plays roles in cell adhesion, migration, and signaling, contributing to processes like angiogenesis, immune response, and cancer progression. Its structure includes five extracellular immunoglobulin-like domains, a transmembrane region, and a short cytoplasmic tail.
In cancer biology, MCAM is linked to tumor metastasis by promoting epithelial-mesenchymal transition (EMT) and enhancing cell invasiveness. It interacts with signaling pathways such as Wnt/β-catenin and PI3K/AKT, influencing tumor growth and survival. In vascular biology, MCAM regulates endothelial cell permeability and angiogenesis, making it relevant in diseases like diabetic retinopathy and atherosclerosis.
MCAM antibodies are essential tools for research and clinical applications. They enable detection of MCAM expression in tissues or circulating tumor cells, aiding cancer diagnosis and prognosis. Therapeutic antibodies targeting MCAM are under investigation to block tumor metastasis or disrupt pathological angiogenesis. Additionally, MCAM's role in autoimmune diseases, such as multiple sclerosis, highlights its potential as a therapeutic target for modulating immune cell trafficking. Overall, MCAM antibodies bridge mechanistic studies and translational medicine across oncology, immunology, and vascular biology.
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