| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GSC |
| Entrez GeneID | 145258 |
| clone | 4C5D5 |
| WB Predicted band size | 28.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GSC (AA: 191-257) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于GSC(胶质母细胞瘤干细胞)抗体的3篇代表性文献的简要总结(文献信息为模拟示例，仅供参考)：
1. **文献名称**：*Targeting glioblastoma stem cells with monoclonal antibodies against CD133*
**作者**：Wang et al.
**摘要**：本研究开发了一种靶向CD133表面抗原的单克隆抗体，证实其能特异性识别并抑制GSC的自我更新能力，为胶质母细胞瘤的靶向治疗提供新策略。
2. **文献名称**：*Novel anti-L1CAM antibody inhibits invasion of glioblastoma stem cells*
**作者**：Bao et al.
**摘要**：通过筛选特异性结合GSC的L1CAM蛋白抗体，发现该抗体可阻断肿瘤干细胞迁移和侵袭，并增强放疗敏感性。
3. **文献名称**：*EGFRvIII-specific CAR-T cells combined with anti-GSC antibodies improve glioblastoma outcomes*
**作者**：Johnson et al.
**摘要**：联合使用靶向GSC表面抗原的抗体与CAR-T细胞疗法，显著降低肿瘤复发率，揭示了抗体在协同免疫治疗中的潜力。
4. **文献名称**：*Identification of a GSC-specific epitope via phage display antibody screening*
**作者**：Chen et al.
**摘要**：利用噬菌体展示技术筛选出高亲和力GSC特异性抗体，验证其在肿瘤组织中的靶向性，为诊断试剂开发奠定基础。
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**注**：以上文献为示例性质，实际研究中请通过PubMed或Google Scholar以关键词“glioblastoma stem cell antibody”“GSC marker”等检索最新文献。
The Goosecoid (GSC) antibody is a critical tool in developmental biology and biomedical research, targeting the Goosecoid protein encoded by the *GSC* gene. Discovered in the early 1990s, Goosecoid is a transcription factor belonging to the homeobox gene family, playing a pivotal role in embryonic development, particularly in establishing the organizer region during gastrulation. It regulates cell fate determination, tissue patterning, and craniofacial morphogenesis by modulating downstream genes involved in cell migration and differentiation.
GSC antibodies are widely used to detect and localize the Goosecoid protein in various experimental models, including vertebrates like mice, zebrafish, and Xenopus. These antibodies enable researchers to study protein expression dynamics via techniques such as immunohistochemistry, Western blotting, and immunofluorescence. Their application has shed light on developmental abnormalities, congenital disorders, and cancer, where dysregulation of GSC is linked to tumor progression and metastasis.
Commercial and custom GSC antibodies are typically raised in rabbits or mice, with validation emphasizing specificity through knockout controls or peptide-blocking assays. Despite their utility, challenges remain in cross-reactivity across species and ensuring consistent performance in diverse tissue contexts. Ongoing research continues to refine these tools, enhancing their reliability for both basic science and clinical diagnostics.
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