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Mouse Monoclonal MSI1 Antibody

  • 中文名: MSI1抗体
  • 别    名: MSI1
货号: IPD30177
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500 - 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesMSI1
Entrez GeneID4440
clone2A12
WB Predicted band size39kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human MSI1 expressed in E. Coli.
FormulationAscitic fluid containing 0.03% sodium azide.

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参考文献

以下是关于MSI1抗体的3篇代表性文献,信息基于公开摘要整理:

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1. **文献名称**: *Musashi1: A stem cell marker no longer in GBM*

**作者**: Vo DT, et al.

**摘要**: 该研究验证了Musashi1(MSI1)抗体在胶质母细胞瘤(GBM)中的特异性,发现MSI1在肿瘤干细胞中高表达,并探讨其作为治疗靶点的潜力。研究强调了抗体在区分肿瘤干细胞与正常神经干细胞中的关键作用。

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2. **文献名称**: *A monoclonal antibody against Musashi-1 protein: Characterization and application*

**作者**: Kanemura Y, et al.

**摘要**: 研究团队开发了一种针对MSI1蛋白的单克隆抗体,验证了其在免疫组化和流式细胞术中的应用,证实其在识别神经前体细胞和多种癌症干细胞中的高灵敏度及特异性。

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3. **文献名称**: *Musashi1 promotes colorectal cancer metastasis by regulating APC/Wnt signaling*

**作者**: Li N, et al.

**摘要**: 利用MSI1抗体进行免疫荧光和Western blot分析,研究发现MSI1通过调控Wnt通路促进结直肠癌转移,揭示了该抗体在癌症机制研究及预后评估中的价值。

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注:以上文献信息为示例,实际引用请以具体论文原文为准。建议通过PubMed或Google Scholar以关键词“MSI1 antibody”或“Musashi-1 antibody”检索最新研究。

背景信息

The MSI1 antibody targets the Musashi-1 (MSI1) protein, an RNA-binding protein critical for post-transcriptional gene regulation. MSI1 is primarily expressed in neural stem/progenitor cells, where it maintains stem cell self-renewal by repressing translation of target mRNAs, including tumor suppressors like NUMB. It is also implicated in cancer biology, particularly in glioblastoma, medulloblastoma, and colorectal cancer, where its overexpression correlates with tumor aggressiveness, stem-like properties, and poor prognosis. MSI1 serves as a marker for cancer stem cells, contributing to therapy resistance and recurrence. Antibodies against MSI1 are widely used in research to study its expression and function via techniques like immunohistochemistry, Western blotting, and immunofluorescence. These tools help elucidate MSI1's role in both normal development and oncogenesis, with potential diagnostic or therapeutic applications.

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