Mouse Monoclonal AURKA Antibody

AURKA (Aurora Kinase A) is a serine/threonine kinase critical for mitotic progression, primarily regulating centrosome maturation, spindle assembly, and chromosomal segregation. Overexpression or dysregulation of AURKA is linked to genomic instability and oncogenesis, making it a biomarker in various cancers, including breast, ovarian, and colorectal cancers. AURKA antibodies are essential tools for detecting and quantifying AURKA expression in research and diagnostics. These antibodies target specific epitopes, such as the kinase domain or regulatory regions, enabling applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study AURKA's localization and activity. In cancer studies, they help correlate AURKA levels with tumor grade, metastasis, and therapeutic resistance. Additionally, AURKA antibodies aid in evaluating inhibitor efficacy in preclinical models and clinical trials. Their specificity is validated through knockout controls or peptide blocking assays to ensure accurate detection. Beyond oncology, AURKA antibodies contribute to understanding developmental disorders and cellular aging linked to mitotic errors. As therapeutic targeting of AURKA gains momentum, these antibodies remain pivotal for mechanistic insights and translational applications in precision medicine.