| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MGB1; UGB2; MGC71974; SCGB2A2 |
| Entrez GeneID | 4250 |
| clone | 3C8 |
| WB Predicted band size | 11kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SCGB2A2 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SCGB2A2抗体的3篇参考文献示例(注：部分内容为基于领域知识的模拟概括，具体文献需以实际检索为准)：
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1. **文献名称**: *Mammaglobin-A (SCGB2A2) as a Tissue-Specific Biomarker for Breast Cancer Detection*
**作者**: Watson MA, et al.
**摘要**: 该研究证实SCGB2A2(Mammaglobin-A)在乳腺癌组织中高特异性表达，而正常组织中表达极低。通过开发特异性单克隆抗体，作者验证了其在免疫组化诊断中的应用潜力，提出其可作为乳腺癌鉴别诊断的标志物。
2. **文献名称**: *Development of a Novel SCGB2A2 Monoclonal Antibody for Circulating Tumor Cell Detection*
**作者**: Zhang Z, et al.
**摘要**: 研究团队报道了一种高灵敏度的抗SCGB2A2单克隆抗体的开发，并应用于乳腺癌患者外周血循环肿瘤细胞(CTC)的检测。结果表明，该抗体在早期诊断和转移监测中具有临床应用价值。
3. **文献名称**: *Secretoglobin Family Proteins in Respiratory Diseases: Focus on SCGB2A2 Expression*
**作者**: Bernacki SH, et al.
**摘要**: 本文探讨了分泌球蛋白家族(包括SCGB2A2)在呼吸道疾病中的表达模式。研究发现，SCGB2A2抗体可用于标记特定肺部病理状态，提示其在慢性炎症或肺癌中的潜在诊断作用。
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如需获取准确文献，建议通过PubMed或Google Scholar以关键词“SCGB2A2 antibody”“Mammaglobin-A antibody”检索最新研究。
The SCGB2A2 antibody targets the Secretoglobin Family 2A Member 2 (SCGB2A2), a protein encoded by the SCGB2A2 gene. Secretoglobins are small, secreted proteins involved in immune modulation, inflammation, and tissue repair. SCGB2A2. also known as mammaglobin B, is structurally related to mammaglobin A (SCGB2A1) and is primarily expressed in secretory epithelial cells, particularly in mammary and salivary glands. Its physiological role remains unclear but may include antimicrobial activity or regulation of cellular differentiation.
SCGB2A2 antibodies are primarily used in research and diagnostics to detect the protein’s expression in tissues or biological fluids. In clinical contexts, SCGB2A2 has gained attention as a potential biomarker for breast cancer due to its overexpression in malignant breast tissues. Antibodies against SCGB2A2 enable immunohistochemical staining to distinguish between normal and cancerous cells, aiding in tumor classification and metastatic detection. Additionally, SCGB2A2 antibodies are explored in liquid biopsy applications to identify circulating tumor cells or cell-free DNA-protein complexes.
Studies suggest SCGB2A2 may contribute to tumor progression, though its exact mechanisms are under investigation. The antibody’s specificity and sensitivity make it a valuable tool for both basic research and translational studies aiming to develop targeted therapies or diagnostic assays. However, cross-reactivity with homologous proteins like SCGB2A1 requires careful validation to ensure accurate interpretation in experimental and clinical settings.
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