| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Sep15; 9430015P09Rik |
| Entrez GeneID | 93684 |
| WB Predicted band size | Calculated MW: 18 kDa; Observed MW: 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of mouse SEP15 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与EGF抗体相关的研究文献概览：
1. **《Anti-epidermal growth factor receptor monoclonal antibody cetuximab in the treatment of human cancers》**
- 作者：Mendelsohn, J., & Baselga, J.
- 摘要：研究总结了西妥昔单抗(抗EGFR单抗)在癌症治疗中的作用，通过阻断EGFR信号通路抑制肿瘤生长，临床应用于结直肠癌和头颈部鳞癌，并探讨了疗效预测标志物(如KRAS突变状态)。
2. **《Development of a high-affinity anti-EGF antibody for improved cancer targeting》**
- 作者：Li, X., et al.
- 摘要：报道了一种新型高亲和力抗EGF抗体的开发，通过噬菌体展示技术优化，体外实验显示其有效中和EGF并抑制肿瘤细胞增殖，动物模型中显著减少肺癌移植瘤体积。
3. **《EGF receptor-targeted immunoconjugates for tumor imaging》**
- 作者：Cunningham, S., et al.
- 摘要：构建了抗EGFR抗体-放射性核素偶联物(如¹¹¹In标记)，在卵巢癌模型中实现高特异性肿瘤显像，为靶向诊疗一体化提供实验依据，对比传统成像显示灵敏度提升。
注：以上为虚拟示例，实际文献需通过PubMed/Google Scholar检索关键词(如"EGF antibody", "EGFR monoclonal antibody", "therapeutic applications")获取。经典文献可参考西妥昔单抗(Cetuximab)或帕尼单抗(Panitumumab)的临床试验论文。
Epidermal Growth Factor (EGF) antibodies are specialized proteins designed to target and bind to EGF, a key signaling molecule involved in cell proliferation, differentiation, and survival. EGF exerts its effects by binding to the EGF receptor (EGFR), a transmembrane tyrosine kinase receptor overexpressed in many cancers, driving uncontrolled cell growth. EGF antibodies block this interaction, inhibiting downstream signaling pathways like MAPK and PI3K/AKT, thereby suppressing tumor progression.
These antibodies are categorized as monoclonal (e.g., cetuximab, panitumumab) or polyclonal, with monoclonal antibodies being widely used in clinical settings due to their specificity. They play a critical role in targeted cancer therapies, particularly for EGFR-overexpressing malignancies such as colorectal, lung, and head/neck cancers. Beyond therapeutics, EGF antibodies are employed in diagnostic assays to detect EGFR expression levels in tumors, aiding in patient stratification for personalized treatment.
Research applications include studying EGFR signaling mechanisms and validating experimental models. However, challenges like drug resistance and variable patient responses drive ongoing research to optimize efficacy. Overall, EGF antibodies represent a cornerstone in both oncological therapeutics and molecular research, bridging translational medicine and basic science.
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