| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ARG; ABLL; FLJ22224; FLJ31718; FLJ41441 |
| Entrez GeneID | 27 |
| clone | 1H1 |
| WB Predicted band size | 128kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of ABL2 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ABL2抗体的3篇示例参考文献(注：以下内容为模拟示例，非真实文献)：
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1. **文献名称**：*"Development of a High-Specificity Antibody for ABL2 Kinase Detection in Solid Tumors"*
**作者**：Zhang, L. et al.
**摘要**：本研究报道了一种新型兔源单克隆抗体的开发，该抗体针对ABL2激酶的C端结构域，具有高特异性和低交叉反应性。通过免疫组化和蛋白质印迹验证，该抗体成功用于检测多种实体瘤中ABL2的异常表达及其与肿瘤转移的相关性。
2. **文献名称**：*"ABL2 Regulates Neuronal Morphogenesis via Antibody-Validated Phosphorylation Targets"*
**作者**：Martinez, R. & Lee, J.
**摘要**：文章利用特异性ABL2抗体揭示了ABL2激酶在大脑神经元突触重塑中的作用，通过质谱分析鉴定了ABL2在神经元发育中的关键磷酸化底物，并证明其缺失导致小鼠模型中的认知功能缺陷。
3. **文献名称**：*"A Novel Anti-ABL2 Antibody Inhibits Drug-Resistant Leukemia Cell Proliferation In Vitro"*
**作者**：Chen, H. et al.
**摘要**：团队开发了一种人源化ABL2中和抗体，可特异性阻断ABL2与底物蛋白的相互作用。实验表明，该抗体在体外显著抑制伊马替尼耐药的白血病细胞增殖，为靶向ABL2的治疗策略提供了依据。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“ABL2 antibody”或“ARG kinase antibody”，并筛选近年的实验研究论文。
The ABL2 antibody is a crucial tool in studying the ABL2 kinase (also known as ABL-related gene, ARG), a non-receptor tyrosine kinase closely related to ABL1. Both kinases share structural homology, including SH2 and SH3 domains, and regulate cellular processes such as cytoskeletal remodeling, cell migration, proliferation, and stress response. Unlike ABL1. which is well-known for its oncogenic role in chronic myeloid leukemia (CML) via the BCR-ABL1 fusion protein, ABL2 has distinct functions in neuronal development and cancer progression, particularly in solid tumors. Dysregulation of ABL2 is linked to metastasis, drug resistance, and aberrant signaling pathways (e.g., RAS/MAPK, PI3K/AKT).
ABL2 antibodies are designed to detect endogenous ABL2 proteins in various experimental applications, including Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. These antibodies often target specific epitopes, such as the kinase domain or C-terminal regions, to distinguish ABL2 from ABL1 or assess phosphorylation status. Researchers use ABL2 antibodies to explore its role in diseases, evaluate therapeutic targets, or monitor kinase inhibition in preclinical models. Challenges include cross-reactivity with ABL1 and variability in detection due to tissue-specific expression. Validated antibodies are critical for elucidating ABL2's context-dependent functions and advancing targeted therapies.
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