Mouse Monoclonal RTN3 Antibody

The RTN3 antibody is a research tool targeting reticulon 3 (RTN3), a member of the reticulon protein family. Reticulons are primarily localized to the endoplasmic reticulum (ER) and play roles in maintaining ER structure, vesicle trafficking, and cellular processes like apoptosis and axonal regeneration. RTN3. encoded by the RTN3 gene, is particularly noted for its involvement in neurological disorders, including Alzheimer’s disease (AD). It interacts with β-secretase (BACE1), a key enzyme in amyloid precursor protein (APP) processing, influencing β-amyloid (Aβ) plaque formation—a hallmark of AD pathology. RTN3 antibodies are widely used to investigate its expression, localization, and function in both healthy and disease contexts, such as AD models. These antibodies are essential for techniques like Western blotting, immunohistochemistry, and immunofluorescence to study RTN3's role in ER stress, neurodegeneration, and autophagy. Challenges in RTN3 antibody development include ensuring specificity, as reticulon family members share structural homology. Recent studies also explore RTN3's dual roles in neuroprotection (via ER stress modulation) and neurotoxicity (linked to dystrophic neurites in AD). Its association with metabolic diseases, cancer, and muscular disorders further expands research applications. Validated RTN3 antibodies thus serve as critical reagents for unraveling its pathophysiological mechanisms and potential therapeutic targets.