| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | fibrinogen beta chain |
| Entrez GeneID | 2244 |
| clone | 1F9 |
| WB Predicted band size | 52kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human FGB (aa30-300) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与FGB(纤维蛋白原β链)抗体相关的文献摘要示例(文献名称与内容为虚构，仅作示例参考)：
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1. **文献名称**：*Autoantibodies targeting fibrinogen β chain in antiphospholipid syndrome: Clinical correlations and pathogenic mechanisms*
**作者**：Chen L, et al.
**摘要**：研究报道抗FGB抗体在抗磷脂综合征(APS)患者中的高检出率，发现其与复发性血栓形成及妊娠并发症显著相关。机制研究表明，该抗体通过干扰纤维蛋白原功能促进血栓形成，提示其作为APS辅助诊断标志物的潜力。
2. **文献名称**：*Prognostic value of anti-fibrinogen β antibodies in sepsis-induced coagulopathy*
**作者**：Wang Y, et al.
**摘要**：分析脓毒症患者血浆发现，抗FGB抗体水平升高与凝血功能障碍和器官衰竭风险正相关。实验表明抗体可能通过激活内皮细胞炎症通路加剧病理过程，为靶向治疗提供新方向。
3. **文献名称**：*Fibrinogen β-chain autoantibodies promote tumor metastasis via macrophage polarization*
**作者**：Kim S, et al.
**摘要**：首次揭示抗FGB抗体通过结合肿瘤微环境中的纤维蛋白原β链，诱导巨噬细胞向促癌表型转化，加速肿瘤细胞侵袭转移。动物模型验证抗体阻断可显著抑制转移灶形成。
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注：以上文献为示例性内容，实际研究中请通过PubMed、Web of Science等数据库检索真实文献。若需具体文章推荐，建议补充研究场景(如疾病领域或实验类型)。
Fibrinogen beta chain (FGB) antibodies are immunological tools targeting the beta subunit of fibrinogen, a critical plasma glycoprotein essential for blood coagulation. Fibrinogen, composed of two sets of alpha (FGA), beta (FGB), and gamma (FGG) chains, is synthesized primarily in the liver and converted by thrombin into fibrin during clot formation. The beta chain, encoded by the FGB gene, plays a key role in fibrin polymerization and platelet aggregation.
FGB antibodies are widely utilized in research and diagnostics to investigate fibrinogen-related disorders. Mutations in FGB are linked to congenital fibrinogen deficiencies (afibrinogenemia or hypofibrinogenemia) or dysfibrinogenemias, which manifest as bleeding or thrombotic complications. Additionally, abnormal fibrinogen levels are associated with liver disease, disseminated intravascular coagulation (DIC), and cardiovascular diseases.
In research, FGB antibodies enable the detection and quantification of fibrinogen in biological samples via techniques like ELISA, Western blot, and immunohistochemistry. They also aid in studying fibrinogen’s role in inflammation, wound healing, and cancer metastasis, where fibrinogen fragments may influence cellular adhesion and angiogenesis. Autoantibodies against fibrinogen, though rare, have been reported in autoimmune conditions, highlighting their diagnostic relevance.
Commercial FGB antibodies are typically developed in hosts like rabbits or mice, with applications spanning basic science, clinical diagnostics, and therapeutic development targeting coagulation pathways.
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