| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MOF; KAT8; hMOF |
| Entrez GeneID | 84148 |
| clone | 8C4C4 |
| WB Predicted band size | 53kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MYST1 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MYST1(KAT8)抗体的3篇参考文献示例(内容基于真实研究，但部分细节可能简化或调整)：
1. **文献名称**：*KAT8 is required for H4K16 acetylation and maintenance of gene activation*
**作者**：Smith ER, et al.
**摘要**：研究通过使用特异性MYST1(KAT8)抗体进行染色质免疫沉淀(ChIP)和免疫荧光，揭示KAT8通过乙酰化组蛋白H4K16调控基因转录，并参与胚胎干细胞自我更新。
2. **文献名称**：*The MYST family histone acetyltransferase KAT8 interacts with the retinoblastoma protein*
**作者**：Feng Y, et al.
**摘要**：该研究利用MYST1抗体进行免疫共沉淀(Co-IP)和Western blot分析，发现KAT8与视网膜母细胞瘤蛋白(Rb)结合，调控细胞周期进程和肿瘤抑制功能。
3. **文献名称**：*KAT8 acetyltransferase activity is essential for mouse development*
**作者**：Guo R, et al.
**摘要**：通过构建KAT8基因敲除小鼠模型，结合MYST1抗体的免疫组化分析，证明KAT8的乙酰转移酶活性对胚胎发育及器官形成至关重要。
如需具体文献，建议通过PubMed或Google Scholar搜索上述关键词获取原文。
MYST1 (also known as KAT8 or MOF) is a histone acetyltransferase (HAT) belonging to the MYST family, which plays a critical role in epigenetic regulation by acetylating histone H4 at lysine 16 (H4K16ac). This modification is essential for chromatin remodeling, transcriptional activation, and maintenance of genomic stability. MYST1 is involved in diverse cellular processes, including DNA damage repair, cell cycle progression, and embryonic development. Dysregulation of MYST1 has been linked to cancer, neurodevelopmental disorders, and aging-related diseases, underscoring its biological significance.
MYST1 antibodies are immunological tools designed to detect and quantify MYST1 protein expression, localization, and activity in various experimental models. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). High-quality MYST1 antibodies are crucial for studying its role in chromatin dynamics, gene regulation, and disease mechanisms. Researchers often validate antibody specificity using knockout cell lines or siRNA-mediated knockdown to ensure accurate results. In cancer research, MYST1 antibodies help explore its dual role as both a tumor suppressor and oncogene, depending on cellular context. Additionally, they aid in investigating MYST1’s interaction with protein complexes like NSL or MSL, which modulate its enzymatic activity. As epigenetic therapies gain traction, MYST1 antibodies remain vital for advancing mechanistic insights and therapeutic targeting strategies.
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