| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | DKFZp686D0638; GSK3A |
| Entrez GeneID | 2931 |
| clone | 9D5G1 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of GSK3 alpha expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于GSK3α抗体的参考文献及其摘要的简要列举：
1. **"GSK3α regulates tumorigenesis and metastasis by controlling the SHH and mTOR pathways in lung adenocarcinoma"**
- **作者**: Zhang Y, et al.
- **摘要**: 该研究通过特异性GSK3α抗体分析肺癌组织样本，揭示了GSK3α通过调控SHH和mTOR信号通路促进肿瘤生长和转移的机制，强调了其作为潜在治疗靶点的价值。
2. **"Selective role of GSK3α in mitochondrial function and energy metabolism"**
- **作者**: Beurel E, et al.
- **摘要**: 利用GSK3α特异性抗体进行免疫沉淀和Western blot实验，研究发现GSK3α(而非GSK3β)通过调节线粒体复合物活性影响能量代谢，为代谢性疾病提供了新见解。
3. **"A GSK3α-specific antibody reveals distinct phosphorylation patterns in Alzheimer's disease models"**
- **作者**: Hernández F, et al.
- **摘要**: 研究采用高特异性GSK3α抗体，发现阿尔茨海默病模型中GSK3α对tau蛋白的异常磷酸化作用，提示其与神经退行性病变的关联，为抗体在病理检测中的可靠性提供了依据。
4. **"Differential roles of GSK3 isoforms in cardiac hypertrophy"**
- **作者**: Zhai P, et al.
- **摘要**: 通过GSK3α和GSK3β抗体的对比实验，研究证实GSK3α特异性调控心肌肥厚相关基因表达，而GSK3β主要参与凋亡通路，突显抗体在亚型功能区分中的关键作用。
这些文献均直接涉及GSK3α抗体的应用，涵盖肿瘤、代谢、神经疾病及心脏病理等领域，验证了抗体的特异性及功能研究价值。
**Background of GSK3α Antibody**
Glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, exists as two isoforms, GSK3α and GSK3β, which share structural similarity but differ in regulatory roles and substrate specificity. GSK3α, encoded by the *GSK3A* gene, regulates diverse cellular processes, including metabolism, cell proliferation, and apoptosis, by phosphorylating substrates like β-catenin, glycogen synthase, and transcription factors. Unlike GSK3β, GSK3α has a unique glycine-rich N-terminal extension, influencing its interaction with signaling pathways such as Wnt, insulin, and PI3K/AKT.
Antibodies targeting GSK3α are essential tools for detecting its expression, post-translational modifications (e.g., phosphorylation at Ser21), and subcellular localization in studies of diseases like diabetes, cancer, and neurodegenerative disorders. These antibodies are validated for specificity to distinguish GSK3α from GSK3β, ensuring accurate analysis in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using GSK3α antibodies has highlighted its distinct role in pathologies, such as modulating amyloid-beta production in Alzheimer’s disease and insulin resistance in metabolic syndromes. Such studies underscore its potential as a therapeutic target, driving demand for reliable detection tools to explore isoform-specific functions and drug development strategies.
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