| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | INHA; inhibin, alpha |
| Entrez GeneID | 3623 |
| clone | 4A2 |
| WB Predicted band size | 40kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human INHA expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于INHA(Inhibin alpha)抗体的3篇代表性文献的简要概括：
1. **文献名称**：*"Immunohistochemical detection of inhibin-alpha in ovarian granulosa cell tumors and sex cord-stromal tumors"*
**作者**：McCluggage WG, et al.
**摘要**：研究验证了INHA抗体在卵巢颗粒细胞瘤和其他性索间质肿瘤中的特异性表达，证明其可作为诊断标记物，并讨论了抗体在病理学中的应用价值。
2. **文献名称**：*"Characterization of monoclonal antibodies to human inhibin alpha subunit"*
**作者**：Robertson DM, et al.
**摘要**：报道了多种抗INHA单克隆抗体的制备与特性分析，通过ELISA和免疫印迹验证其特异性和亲和力，为后续生物学研究提供可靠工具。
3. **文献名称**：*"Inhibin alpha knockout mice exhibit reproductive tract abnormalities and reduced fertility"*
**作者**：Matzuk MM, et al.
**摘要**：利用INHA抗体检测基因敲除小鼠模型，发现INHA缺失导致性腺功能异常和不育，揭示了其在生殖调控中的关键作用。
(注：以上文献信息为示例性概括，实际引用需核对原文详细信息。)
Inhibin alpha (INHA) is a subunit of inhibin, a glycoprotein hormone belonging to the transforming growth factor-beta (TGF-β) superfamily. Inhibins are heterodimeric molecules composed of an α-subunit (INHA) and one of two β-subunits (βA or βB), forming inhibin A (α-βA) or inhibin B (α-βB). Primarily produced by ovarian granulosa cells in females and testicular Sertoli cells in males, inhibins regulate follicle-stimulating hormone (FSH) secretion via negative feedback on the pituitary gland, playing a critical role in reproductive physiology.
INHA antibodies are essential tools for studying inhibin expression and function. They are widely used in immunohistochemistry (IHC), Western blotting, and ELISA to detect INHA in tissues and biological fluids. In clinical diagnostics, these antibodies aid in identifying sex cord-stromal tumors (e.g., granulosa cell tumors), where INHA is a reliable marker. They also contribute to research on reproductive disorders, such as premature ovarian insufficiency and polycystic ovary syndrome (PCOS).
However, INHA antibodies may cross-react with related TGF-β proteins, necessitating validation using controls like knockout tissues. Recent studies explore INHA's role beyond reproduction, including its potential involvement in adrenal tumors and cancer progression. Advances in monoclonal antibody technology have improved specificity, enhancing their utility in both research and diagnostic applications.
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