| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MGC10442 |
| Entrez GeneID | 640 |
| clone | 9D10B7H6 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of BLK expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于BLK抗体的3-4篇参考文献示例(内容为虚构，仅供参考)：
1. **文献名称**：*"BLK基因变异与系统性红斑狼疮的关联研究"*
**作者**：Hom G. et al.
**摘要**：通过全基因组关联分析(GWAS)，发现BLK基因的单核苷酸多态性(SNP)与系统性红斑狼疮(SLE)的发病风险显著相关。研究揭示了BLK在B细胞受体信号传导中的作用，其表达降低可能导致B细胞过度活化，从而参与自身免疫反应。
2. **文献名称**：*"B淋巴细胞激酶(BLK)在B细胞发育中的功能调控"*
**作者**：Cornall R.J. et al.
**摘要**：利用基因敲除小鼠模型，研究发现BLK缺失导致未成熟B细胞分化受阻，并影响B细胞受体(BCR)信号通路的激活。该文献强调了BLK在早期B细胞发育和免疫耐受中的关键作用。
3. **文献名称**：*"靶向BLK的抗体在自身免疫疾病治疗中的潜力"*
**作者**：Simmons M.J. et al.
**摘要**：研究开发了一种特异性识别BLK蛋白的单克隆抗体，实验显示其可抑制B细胞异常活化和炎症因子分泌。动物模型表明，该抗体能减轻类风湿性关节炎症状，提示BLK可能成为自身免疫疾病的治疗靶点。
4. **文献名称**：*"BLK表达调控机制及其在B细胞恶性肿瘤中的异常"*
**作者**：Hikida M. et al.
**摘要**：通过分析B细胞淋巴瘤样本，发现BLK表达水平与肿瘤进展相关。研究揭示了miRNA介导的BLK转录后调控机制，并探讨了BLK抑制剂在癌症治疗中的应用前景。
(注：以上文献信息为模拟示例，实际研究中请通过学术数据库核实具体内容。)
The B lymphocyte kinase (BLK) gene encodes a non-receptor tyrosine kinase belonging to the Src family, primarily expressed in B cells. It plays a critical role in B cell receptor (BCR) signaling, influencing B cell development, differentiation, and immune response regulation. BLK activates downstream pathways, including MAPK and NF-κB, through phosphorylation events that modulate cell proliferation and survival. Dysregulation of BLK has been implicated in autoimmune disorders, particularly systemic lupus erythematosus (SLE) and rheumatoid arthritis. Genome-wide association studies (GWAS) have identified BLK as a susceptibility locus, with specific polymorphisms correlating to altered gene expression and autoimmune risk.
Anti-BLK antibodies, either as research tools or potential biomarkers, are used to study BLK's function in immune pathways. In autoimmune contexts, autoantibodies targeting BLK or cross-reacting epitopes may contribute to disease pathogenesis by disrupting B cell signaling. Therapeutic strategies targeting BLK, such as small-molecule inhibitors, are under exploration to modulate aberrant B cell activity. However, the precise role of BLK autoantibodies in clinical diagnostics or therapeutics remains an active area of investigation, requiring further mechanistic and translational studies.
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