Mouse Monoclonal Fibulin5 Antibody

Fibulin 5 (FBLN5), a secreted extracellular matrix (ECM) protein, belongs to the fibulin family and plays a critical role in elastogenesis by organizing elastin fibers and mediating cell-ECM interactions. It binds integrins and tropoelastin, facilitating elastic fiber assembly and maintaining tissue elasticity. Fibulin 5 is highly expressed in elastic tissues, including skin, blood vessels, and lungs. Dysregulation or mutations in FBLN5 are linked to age-related elastinopathies, such as cutis laxa, cardiovascular disorders, and chronic obstructive pulmonary disease (COPD). Fibulin 5 antibodies are essential tools for studying its expression, localization, and function in tissue development and disease. Researchers use these antibodies in techniques like immunohistochemistry, Western blotting, and immunofluorescence to investigate Fibulin 5's role in ECM remodeling, cell adhesion, and signaling pathways. Additionally, they aid in diagnosing genetic elastin-related disorders and exploring therapeutic strategies targeting ECM homeostasis. Recent studies also implicate Fibulin 5 in tumor suppression and metastasis, broadening its relevance in cancer research. Antibodies specific to Fibulin 5 help elucidate its dual roles in maintaining structural integrity and modulating cellular behavior, underscoring its importance in both physiological and pathological contexts.