| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ASPCR1, ASPL, ASPS, RCC17, TUG, UBXD9, UBXN9 |
| Entrez GeneID | 79058 |
| clone | 4A11A6G11 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | Purified recombinant fragment of TUG expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于小鼠TUG抗体的参考文献示例(注：以下为模拟文献，实际引用时请核实真实来源)：
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1. **文献名称**：*TUG Protein Regulates GLUT4 Trafficking and Insulin Action in Mouse Adipocytes*
**作者**：Bogan JS, et al.
**摘要**：该研究利用小鼠TUG抗体，通过免疫沉淀和免疫印迹技术揭示了TUG蛋白在胰岛素刺激下调控脂肪细胞中GLUT4囊泡转运的关键作用，证实TUG缺失导致葡萄糖摄取障碍。
2. **文献名称**：*Characterization of a Novel Monoclonal Antibody Against Mouse Tethering UDP-Glucose Protein*
**作者**：Xu Y, et al.
**摘要**：本文报道了一种特异性识别小鼠TUG蛋白的单克隆抗体的开发与验证，通过免疫荧光和流式细胞术证明其在多种组织中的高灵敏度和特异性，为TUG功能研究提供工具。
3. **文献名称**：*TUG-Mediated ER Retention in Neuronal Development of Mice*
**作者**：Saito T, et al.
**摘要**：研究采用TUG抗体结合免疫组化技术，发现TUG蛋白通过调控内质网滞留影响小鼠神经元突触形成，抗体验证了TUG在脑组织中的时空表达模式。
4. **文献名称**：*TUG Knockout Mice Exhibit Metabolic Syndrome Phenotypes: Insights from Antibody-Based Proteomic Analysis*
**作者**：Chen L, et al.
**摘要**：通过TUG抗体进行蛋白质组学分析，发现TUG基因敲除小鼠出现胰岛素抵抗和脂代谢紊乱，提示TUG在代谢稳态中的关键作用。
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如需真实文献，建议通过PubMed或Google Scholar以关键词“TUG antibody mouse”、“Tethering UDP-glucose protein mouse”进一步检索，并筛选涉及抗体应用的实验研究。
Mouse TUG (Tether containing UDP Glucose) antibody is designed to detect the TUG protein, a key regulator of glucose transporter 4 (GLUT4) trafficking in insulin-sensitive tissues. Discovered in the early 2000s, TUG acts as a molecular tether that anchors intracellular GLUT4 storage vesicles (GSVs) within adipocytes and myocytes under basal conditions. Upon insulin stimulation, TUG undergoes proteolytic cleavage, releasing GSVs to translocate to the cell membrane, facilitating glucose uptake—a critical process in glucose homeostasis. Dysregulation of TUG-mediated GLUT4 trafficking is implicated in insulin resistance and type 2 diabetes.
The mouse TUG antibody specifically targets murine TUG isoforms (e.g., ~50 kDa full-length protein or cleavage products) and is widely used in metabolic research to study insulin signaling, adipose biology, and skeletal muscle function. It enables detection via techniques like Western blotting, immunofluorescence, or immunohistochemistry in mouse models of obesity, diabetes, or genetic modifications. Validated for specificity, this tool has advanced understanding of TUG's dual roles in vesicle trafficking and transcriptional regulation, as well as its interaction with proteins like Usp25m. Its application aids in exploring therapeutic strategies targeting GLUT4 dynamics in metabolic disorders.
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