关键信息
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基因名
CD74
- 应用
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别名
MHCDG; HLA-DG; HLADG; DHLAG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; Ia antigen-associated invariant chain; HLA-DR antigens-associated invariant chain
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P04233
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表达区间
Leu78~Val222
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分子量
20kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CD74, also known as the invariant chain, is a membrane protein that plays a critical role in the immune response by facilitating the presentation of antigens to T cells. It serves as a chaperone for Major Histocompatibility Complex (MHC) class II molecules during their synthesis and transport within antigen-presenting cells. In recent years, research has highlighted the multifaceted functions of CD74 beyond its traditional role in immune signaling, including its involvement in cell proliferation, survival, and migration in various pathologies such as cancer and autoimmune diseases. Given its increased expression in several tumors, CD74 has garnered attention as a potential therapeutic target and a biomarker for disease progression. The production of recombinant CD74 proteins allows for detailed studies into its structural and functional properties, as well as its interactions with various ligands and receptors. This biochemical characterization is essential for understanding its role in immune regulation and pathology, thereby paving the way for the development of novel immunotherapeutic strategies. The ongoing exploration of CD74 in both normal physiology and disease states underscores its importance in immunology and highlights its potential as a target for innovative therapeutic interventions.
