关键信息
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基因名
CD82
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简介
CD82, a vital immune response participant, engages with CD4 or CD8 to provide crucial costimulatory signals in the TCR/CD3 pathway. Its direct interaction with IGSF8 plays a pivotal role in modulating immune functions and mediating cellular responses. CD82 Protein, Human (HEK293, His) is the recombinant human-derived CD82 protein, expressed by HEK293 , with C-His labeled tag.
- 应用
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别名
CD82 antigen; C33 antigen; Tspan-27; CD82; KAI1; SAR2; ST6; TSPAN27
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P27701-1
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表达区间
G111-L228
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蛋白长度
Partial
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分子量
25-33 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CD82, also known as lymphocyte function-associated antigen 3 (LFA-3), is a member of the tetraspanin family, which plays a critical role in various biological processes, including cell adhesion, proliferation, and immune response regulation. CD82 is particularly notable for its involvement in modulating the immune system, as it is expressed on various immune cells, including T cells, B cells, and dendritic cells. Research into CD82 has shown its potential role in cancer biology, where it can influence tumor metastasis and progression through its interactions with integrins and other cell surface molecules. Studies indicate that CD82 may function as a tumor suppressor in certain cancer types, as its expression has been associated with reduced metastatic potential and improved patient prognosis. Moreover, the re-expression of CD82 in cancer cells has been linked to enhanced immune response against tumors, suggesting that CD82 could be a valuable target for immunotherapy. Given its important biological functions and potential clinical implications, the production and characterization of recombinant CD82 protein are necessary for further investigations. Recombinant CD82 proteins can be used to study its structural characteristics, ligand interactions, and downstream signaling pathways. Additionally, these proteins may facilitate the development of novel therapeutic strategies by providing insights into CD82's role in immune modulation and cancer progression. Understanding the functioning of recombinant CD82 at the molecular level could pave the way for innovative approaches in treating cancers and improving immunotherapeutic outcomes.
