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| 纯度 | >90%SDS-PAGE. |
| 种属 | Mouse |
| 靶点 | Saal1 |
| Uniprot No | Q9D2C2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-474aa |
| 氨基酸序列 | MDRNPSPPPPTCGSEDEEDLGGGDRIGSTVYSKHWLFGVLSGLIQIVTPESGTSGSADEEEQADLAEEMENEICRVWDMSMDEDVALFLQEFKAPDIFMGVLAKSPCPRLREICVGILGNMACFREICESISKNEDHGQVLLQCLCDSDPPTLLETCRLLLTCLSQTEVASVWVRRIREHPSVYANVCFIMSSSTNVDLLVKVGEVVDKLFDLDEKLMLEWIRKGATRLPGQPHEDSEEQPVFSIVPCVLEAAKQVRSENLEGLDVYMRILQLLTTVDDGVQAIVQCPDTGNDTWRLLFDLVCHEFCQPDDPPVILQEQKTVLASVFSVLSAISASRAEQEHLKIEEGDLPLIDSLIRVLQNMEHCQKKPENPSESDTEEPTICGPTQDDFHMKILKDISCEFLSNIFQVLTKEKVAQGLKEGQLSKQKCSCAFQSLLPLYGPAVEDFVKVVREVDEALADDLEDSFPSVKAQT |
| 预测分子量 | 60.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于Saal1(可能为SAA1或拼写变体)重组蛋白的研究文献，以下是3篇相关示例(注：若为“Saal1”拼写需确认，以下基于SAA1重组蛋白的典型研究整理)：
1. **"Recombinant human serum amyloid A1 (SAA1) primes neutrophils for enhanced oxidative burst"**
- **作者**: Xu, L., et al.
- **摘要**: 研究重组人SAA1蛋白对中性粒细胞功能的影响，发现其通过激活TLR2/4信号通路增强活性氧(ROS)的产生，提示SAA1在炎症调节中的关键作用。
2. **"Expression and purification of biologically active recombinant human serum amyloid A1 in Escherichia coli"**
- **作者**: Wang, Y., et al.
- **摘要**: 描述了一种高效的大肠杆菌表达系统，用于生产可溶性重组SAA1蛋白，并通过质谱和功能实验验证其生物活性，为疾病模型研究提供工具。
3. **"Recombinant SAA1 induces inflammatory cytokine secretion via NF-κB activation in macrophages"**
- **作者**: Kim, J.H., et al.
- **摘要**: 证明重组SAA1通过结合巨噬细胞表面受体触发NF-κB信号通路，促进IL-6、TNF-α等炎症因子释放，提示其在慢性炎症疾病中的病理机制。
**注**：若目标蛋白确为“Saal1”而非SAA1.建议进一步确认名称或提供更多上下文以精准检索文献。部分研究可能使用非标准缩写或特定命名体系。
**Background of SAAL1 Recombinant Protein**
SAAL1 (Serum Amyloid A-Like 1) is a secreted glycoprotein encoded by the *SAAL1* gene, belonging to the serum amyloid A (SAA) family. Unlike classical SAA proteins, which are acute-phase reactants synthesized in the liver during inflammation, SAAL1 is constitutively expressed in various tissues, including the liver, kidney, and immune cells. It plays roles in cell signaling, inflammation modulation, and extracellular matrix interactions.
Structurally, SAAL1 contains a conserved N-terminal region shared with SAA proteins and a unique C-terminal domain, enabling interactions with receptors like TLR2/TLR4 and integrins. Recombinant SAAL1 is produced via genetic engineering in systems like *E. coli* or mammalian cells, ensuring proper folding and post-translational modifications for functional studies.
Research highlights SAAL1's dual role in health and disease. It regulates pro-inflammatory cytokines (e.g., IL-6. TNF-α) and promotes cell migration, linking it to chronic inflammatory conditions (e.g., rheumatoid arthritis) and fibrosis. Conversely, SAAL1 overexpression in cancers correlates with tumor progression and metastasis, suggesting its potential as a therapeutic target or biomarker.
SAAL1 recombinant protein is widely used in *in vitro* studies to dissect signaling pathways, screen drug candidates, and develop diagnostic tools. Its role in sterile inflammation and tissue remodeling remains an active research area, offering insights into therapeutic strategies for fibrosis, autoimmune diseases, and cancer.
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