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Recombinant Human MALD3 protein

  • 中文名: 非特异性脂质转移蛋白(MALD3)重组蛋白
  • 别    名: MALD3;MRVLDC3;MARVEL domain-containing protein 3
货号: PA2000-3384
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点MALD3
Uniprot No Q96A59
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-401aa
氨基酸序列MEDPSGAREPRARPRERDPGRRPHPDQGRTHDRPRDRPGDPRRKRSSDGNRRRDGDRDPERDQERDGNRDRNRDRERERERERDPDRGPRRDTHRDAGPRAGEHGVWEKPRQSRTRDGARGLTWDAAAPPGPAPWEAPEPPQPQRKGDPGRRRPESEPPSERYLPSTPRPGREEVEYYQSEAEGLLECHKCKYLCTGRACCQMLEVLLNLLILACSSVSYSSTGGYTGITSLGGIYYYQFGGAYSGFDGADGEKAQQLDVQFYQLKLPMVTVAMACSGALTALCCLFVAMGVLRVPWHCPLLLVTEGLLDMLIAGGYIPALYFYFHYLSAAYGSPVCKERQALYQSKGYSGFGCSFHGADIGAGIFAALGIVVFALGAVLAIKGYRKVRKLKEKPAEMFEF
预测分子量44,9 kDa
蛋白标签His tag N-Terminus
缓冲液PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于MALD3重组蛋白的假设性参考文献示例(若实际文献不足,建议核对术语准确性或扩展关键词):

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1. **文献名称**:*Cloning and Expression of Recombinant MALD3 Protein in E. coli*

**作者**:Smith J, et al.

**摘要**:研究报道了MALD3基因的克隆及在大肠杆菌中的高效表达,通过亲和层析纯化获得高纯度蛋白,并利用质谱和圆二色谱验证其结构完整性,为功能研究奠定基础。

2. **文献名称**:*MALD3 Recombinant Protein Modulates NF-κB Signaling in Macrophages*

**作者**:Lee H, et al.

**摘要**:体外实验表明,重组MALD3蛋白通过结合TRAF6调控NF-κB通路,显著影响巨噬细胞的炎症因子分泌,提示其在免疫调节中的潜在作用。

3. **文献名称**:*Diagnostic Potential of Recombinant MALD3 in Autoimmune Diseases*

**作者**:Zhang Y, et al.

**摘要**:开发基于重组MALD3的ELISA检测法,用于系统性红斑狼疮患者血清抗体筛查,结果显示与传统方法相比特异性提升20%。

4. **文献名称**:*Crystallographic Analysis of MALD3 for Drug Discovery*

**作者**:Brown K, et al.

**摘要**:成功解析重组MALD3蛋白的晶体结构,筛选出小分子抑制剂候选物,为靶向治疗肿瘤提供新思路。

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**注意**:若"MALD3"为术语拼写或领域特异性缩写错误(如可能指MDA5、MALAT1等),建议结合具体研究方向调整检索关键词。实际应用中需通过PubMed/Google Scholar等平台核实文献。

背景信息

The MALD3 recombinant protein is a engineered form derived from the MAL (Myelin and lymphocyte protein) family, which plays critical roles in membrane trafficking and cellular signaling. MAL proteins are characterized by their four transmembrane domains and involvement in organizing lipid rafts, specialized membrane microdomains essential for signal transduction and vesicle transport. While MALD3 is less characterized compared to its homologs like MAL/MAL2. it is hypothesized to participate in intracellular trafficking pathways, particularly in immune cells such as T lymphocytes, where MAL family members regulate receptor localization and signaling.

Recombinant MALD3 is typically produced using expression systems like Escherichia coli or mammalian cell cultures, followed by purification techniques to ensure high specificity and functionality. Its production enables researchers to study its interactions with other proteins, lipid components, and its role in maintaining membrane architecture. Studies suggest that MAL proteins are implicated in diseases such as cancers and autoimmune disorders, where aberrant membrane trafficking contributes to pathogenesis. For instance, MAL overexpression has been linked to tumor progression, while deficiencies are associated with immune dysregulation. MALD3. as a recombinant tool, offers potential for elucidating these mechanisms or serving as a target for therapeutic intervention. Additionally, it may aid in developing diagnostic assays or screening platforms for drugs targeting membrane-associated pathways. Despite its emerging relevance, further functional studies are needed to fully define MALD3's biological roles and therapeutic utility.

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