| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LYPD6 |
| Uniprot No | Q86Y78 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 23-171aa |
| 氨基酸序列 | AQSRDFTVKDIIYLHPSTTPYPGGFKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRNETDATFATTSPINQTNGHPRCMSVIVSCLWLWLGLML |
| 预测分子量 | 18.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于LYPD6重组蛋白的3篇参考文献示例(注：文献信息为虚构示例，仅供格式参考)：
1. **文献名称**：*LYPD6 Interacts with Wnt Receptors to Modulate Signal Transduction*
**作者**：Smith A, et al.
**摘要**：本研究通过重组LYPD6蛋白体外实验，揭示了其与Wnt受体Frizzled的相互作用，表明LYPD6可能通过调控Wnt/β-catenin通路参与胚胎发育和癌症进程。
2. **文献名称**：*Structural Characterization of Recombinant LYPD6 and Its Role in Nicotinic Acetylcholine Receptor Regulation*
**作者**：Chen L, et al.
**摘要**：利用重组LYPD6蛋白进行晶体结构解析，发现其通过特定的疏水结构域与乙酰胆碱受体结合，调节突触传递和神经肌肉功能。
3. **文献名称**：*LYPD6 Recombinant Protein Enhances Cancer Cell Migration via EGFR Signaling*
**作者**：Wang Y, et al.
**摘要**：通过体外重组LYPD6蛋白处理肿瘤细胞，证实其通过激活EGFR信号通路促进肿瘤细胞迁移，为LYPD6在癌症转移中的作用提供机制依据。
(注：以上文献为模拟内容，实际研究需查阅真实数据库。)
LYPD6 is a member of the Ly6/uPAR (lymphocyte antigen-6/urokinase-type plasminogen activator receptor) protein superfamily, characterized by conserved LU structural domains typically stabilized by disulfide bonds. This secreted or membrane-anchored protein is implicated in modulating cell signaling pathways, particularly through interactions with nicotinic acetylcholine receptors (nAChRs) and other cell surface receptors. LYPD6 is highly expressed in the nervous system, where it influences synaptic plasticity, neuronal development, and neurotransmitter release. Studies also link it to cancer progression, with aberrant expression observed in tumors such as colorectal and hepatocellular carcinomas.
Recombinant LYPD6 protein is engineered using expression systems like mammalian cells or *E. coli* to ensure proper folding of its disulfide-dependent tertiary structure. This bioengineered tool enables researchers to study LYPD6's role in ligand-receptor interactions, notably its ability to enhance or inhibit nAChR activity depending on cellular context. Its involvement in Wnt/β-catenin signaling further highlights its regulatory potential in developmental and oncogenic processes. In neuroscience, recombinant LYPD6 aids in deciphering mechanisms underlying cognitive functions and neurodegenerative diseases. In cancer research, it serves as a target for exploring therapeutic strategies or diagnostic biomarkers. The protein's multifunctional nature and tissue-specific expression patterns make it a compelling subject for both basic research and translational applications.
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