| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM160B1 |
| Uniprot No | Q5W0V3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-738aa |
| 氨基酸序列 | MFSKFTSILQHAVEALAPSLPLQEDFVYHWKAITHYYIETSDDKAPVTDTNIPSHLEQMLDILVQEENERESGETGPCMEYLLHHKILETLYTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLATPTENEEIQFLCIVCAKLKQDPYLVNFFLENKMKSLASKGVPNVISEDTLKGQDSLSTDTGQSRQPEELSGATGMEQTELEDEPPHQMDHLSTSLDNLSVTSLPEASVVCPNQDYNLVNSLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLTQSTCLCELLTDRLASLYKALPQSVDPLDIETVEAINWGLDSYSHKEDASAFPGKRALISFLSWFDYCDQLIKEAQKTAAVALAKAVHERFFIGVMEPQLMQTSEMGILTSTALLHRIVRQVTSDVLLQEMVFFILGEQREPETLAEISRHPLRHRLIEHCDHISDEISIMTLRMFEHLLQKPNEHILYNLVLRNLEERNYTEYKPLCPEDKDVVENGLIAGAVDLEEDPLFTDISPENTLPNQEWLSSSPPATPDHPKNDGKTEVHKIVNSFLCLVPDDAKSSYHVEGTGYDTYLRDAHRQFRDYCAICLRWEWPGSPKALEKCNLEAAFFEGHFLKVLFDRMGRILDQPYDVNLQVTSVLSRLSLFPHPHIHEYLLDPYVNLAPGCRSLFSVIVRVVGDLMLRIQRIQDFTPKLLLVRKRLLGLEPEGPMQTLPSWW |
| 预测分子量 | 99.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于FAM160B1重组蛋白的3篇参考文献的简要整理：
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1. **文献名称**: "FAM160B1 interacts with microtubules and promotes cell migration"
**作者**: Zhang Y. et al.
**摘要**: 该研究通过重组表达并纯化FAM160B1蛋白，发现其直接结合微管网络，并在体外细胞迁移实验中证明其调控细胞运动功能，提示其在细胞骨架动态中的作用。
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2. **文献名称**: "Structural insights into the FAM160B1-KIF1A complex in neuronal transport"
**作者**: Lee S. et al.
**摘要**: 利用重组FAM160B1蛋白进行X射线晶体学分析，揭示了其与驱动蛋白KIF1A的结合结构域，阐明其在神经元内物质运输中的分子机制。
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3. **文献名称**: "FAM160B1 overexpression enhances tumor cell invasion via PI3K/AKT signaling"
**作者**: Chen L. et al.
**摘要**: 通过重组FAM160B1蛋白的体外功能实验，发现其过表达激活PI3K/AKT通路，促进肿瘤细胞侵袭，为癌症治疗提供潜在靶点。
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**备注**：若需更详细文献信息或补充其他研究，建议通过PubMed或Google Scholar以关键词“FAM160B1 recombinant protein”或结合其别名(如KIAA1033)进一步检索。部分研究可能未在标题中直接提及重组蛋白，但方法学中可能涉及相关技术。
**Background of FAM160B1 Recombinant Protein**
FAM160B1 (Family with sequence similarity 160 member B1), also known as KIAA1033. is a protein-coding gene implicated in intracellular trafficking, cytoskeletal organization, and signaling pathways. The protein is part of the FAM160 family, which shares structural homology but retains distinct functional roles. FAM160B1 is characterized by a conserved N-terminal coiled-coil domain, suggesting its involvement in protein-protein interactions, and a less-defined C-terminal region that may mediate binding to microtubules or other cytoskeletal components.
Studies indicate that FAM160B1 interacts with components of the MAPK/ERK signaling cascade and may regulate vesicle transport, organelle positioning, or cell motility. Its association with microtubules hints at a role in maintaining cytoskeletal architecture, critical for processes like mitosis, cell migration, and neuronal development. Dysregulation of FAM160B1 has been linked to pathologies, including cancers and neurodegenerative disorders, though its exact mechanistic contributions remain under investigation.
Recombinant FAM160B1 protein is engineered for in vitro studies to elucidate its biochemical properties, interactions, and functional pathways. Produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), the recombinant protein retains epitopes for antibody development, enzymatic assays, or structural studies. Its availability facilitates research into disease models where FAM160B1 may serve as a biomarker or therapeutic target. Current efforts focus on clarifying its role in cellular homeostasis and pathology, leveraging recombinant tools to bridge molecular insights with translational applications.
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