关键信息
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基因名
CD147
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简介
Basigin/BSG proteins are critical for retinal maturation and development and function as retinal cell receptors for NXNL1, promoting the survival of retinal cone photoreceptors. Basigin/CD147 Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived Basigin/CD147 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.
- 应用
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别名
Basigin; HT7 antigen; Membrane glycoprotein gp42; Bsg
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35613-2
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表达区间
A22-H205
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氨基酸序列
AAGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSH
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蛋白长度
Partial
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分子量
30-45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CD147, also known as basigin or extracellular matrix metalloproteinase inducer (EMMPRIN), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It plays a crucial role in various physiological and pathological processes, including cell proliferation, differentiation, and migration, primarily through its interaction with integrins and other proteins in the extracellular matrix. Research has increasingly focused on CD147 due to its implications in cancer progression, cardiovascular diseases, and inflammatory responses. In particular, CD147 is implicated in promoting tumor progression by enhancing matrix metalloproteinase (MMP) activity, facilitating tumor invasiveness and metastasis. The generation of recombinant CD147 proteins has emerged as a valuable tool for elucidating its functional roles and interactions in these processes. By producing CD147 in a controlled environment, researchers can investigate its structure-function relationships, binding properties, and potential as a therapeutic target. Furthermore, recombinant CD147 can be used in the development of diagnostic assays or targeted drug delivery systems, making it a focal point in both basic and translational research. Understanding CD147's mechanisms may pave the way for novel therapeutic strategies aimed at inhibiting its function in diseases characterized by aberrant cell signaling and extracellular matrix remodeling. Thus, the study of CD147 recombinant proteins not only enhances our comprehension of its biological significance but also contributes to the development of innovative approaches to tackle various diseases.
