首页 / 产品 / 蛋白 / 细胞因子、趋化因子与生长因子
| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | Reg1 |
| Uniprot No | P05451 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 23-166aa |
| 氨基酸序列 | QEAQTELPQARISCPEGTNAYRSYCYYFNEDRETWVDADLYCQNMNSGNL VSVLTQAEGA FVASLIKESGTDDFNVWIGLHDPKKNRRWHWSSGSLVSYKSWGIGAPSSV NPGYCVSLTS STGFQKWKDVPCEDKFSFVCKFKNVDHHHHHH |
| 预测分子量 | 17 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与Reg1重组蛋白相关的文献示例(内容为虚构，仅供格式参考)：
1. **文献名称**：*Reg1重组蛋白促进胰岛β细胞再生的机制研究*
**作者**：Xia Y, et al.
**摘要**：研究证明Reg1重组蛋白通过激活PI3K/Akt信号通路，显著促进糖尿病模型小鼠胰岛β细胞的增殖与功能恢复。
2. **文献名称**：*重组Reg1蛋白在胃癌诊断中的生物标志物潜力*
**作者**：Wang L, et al.
**摘要**：通过临床样本分析发现，Reg1重组蛋白在胃癌患者血清中高表达，可能作为早期诊断的新型标志物。
3. **文献名称**：*高效表达与纯化Reg1重组蛋白的工艺优化*
**作者**：Zhang H, et al.
**摘要**：开发了一种基于大肠杆菌表达系统的Reg1重组蛋白纯化策略，显著提高产量并保留其生物活性。
4. **文献名称**：*Reg1重组蛋白调控肠道干细胞分化的功能解析*
**作者**：Kimura T, et al.
**摘要**：体外实验表明，Reg1重组蛋白通过Wnt/β-catenin通路增强肠道干细胞的自我更新能力，具有组织修复应用潜力。
(注：以上文献为示例，实际引用需查询真实数据库如PubMed或Google Scholar。)
Reg1. also known as Regenerating Islet-derived Protein 1 (REG1A), is a secretory protein belonging to the Reg family, initially identified for its role in pancreatic β-cell regeneration. Discovered in the 1980s, Reg1 is encoded by the REG1A gene in humans and is part of a conserved protein family involved in tissue repair and cellular proliferation. Structurally, it contains a C-lectin-like domain and a short peptide signal sequence, facilitating its secretion into extracellular environments.
Reg1 is predominantly expressed in the pancreas, gastrointestinal tract, and certain neurons. Its primary function revolves in promoting cell growth, survival, and differentiation, particularly in pancreatic β-cells. Studies highlight its upregulation during pancreatic injury or inflammation, suggesting a compensatory mechanism to maintain β-cell mass and insulin secretion. This regenerative capacity has linked Reg1 to diabetes research, as impaired β-cell function is central to the disease. However, dysregulated Reg1 expression is also observed in cancers, including pancreatic, gastric, and colorectal cancers, where it may act as a mitogen or anti-apoptotic factor, complicating its therapeutic implications.
Recombinant Reg1 protein is produced using expression systems like E. coli or yeast, enabling studies on its structure-function relationships and therapeutic potential. Purified Reg1 has been tested in preclinical models to mitigate diabetes or enhance tissue repair. Despite promising applications, challenges persist in understanding its dual roles in regeneration and carcinogenesis, as well as optimizing delivery methods for clinical use. Ongoing research aims to clarify signaling pathways (e.g., involvement of EXTL3 or EGFR) and explore its utility as a biomarker or therapeutic target.
×
