| 纯度 | >90%SDS-PAGE. |
| 种属 | E. coli |
| 靶点 | bnk |
| Uniprot No | P40794 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-303aa |
| 氨基酸序列 | MSISTFNFQFYNYKLSPSSPGFGSTASRSSSSCISELEMDIDEDMSAQPTITSTPKPRFTSQLAVELAKTEPGNGISPLRPKLHTAQKRWSMELREKVLEMSKRNNGQEKPQTARQQEQRQPQEQPLQQEELQHQQQEPTVTDKINFFNKLTNTFESGFSKLMPQASSTNNRFIAMLRTARPQNVATTTANSSTANSFLGSDHSLSGSVTGQVPPPKPKRLSATTAQFATPHVPAMGVGKGGSQRKCSLRRKPSMDKSRATISRQSSSASVRTQNHAIMEDLSLVVPVRLRIAEYEQRISMSA |
| 预测分子量 | 33,5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是为您模拟的关于“BNK重组蛋白”的参考文献示例(注：BNK蛋白相关研究较少，可能需核对术语准确性。以下内容为假设性示例，建议通过学术数据库查询真实文献)：
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1. **文献名称**: *Recombinant BNK Protein Enhances B-Cell Activation in Autoimmune Models*
**作者**: Lee, J. et al.
**摘要**: 研究重组BNK蛋白在B细胞信号通路中的作用，发现其通过调节NF-κB通路增强B细胞活化，可能为自身免疫疾病治疗提供新靶点。
2. **文献名称**: *Expression and Purification of BNK Fusion Protein for Cancer Immunotherapy*
**作者**: Zhang, R. & Patel, S.
**摘要**: 报道了一种新型BNK-IL2融合蛋白的表达与纯化方法，体外实验显示其可显著增强T细胞抗肿瘤活性，具有潜在临床应用价值。
3. **文献名称**: *Structural Characterization of BNK Kinase Domain by X-ray Crystallography*
**作者**: Müller, T. et al.
**摘要**: 通过X射线晶体学解析BNK蛋白激酶结构域的三维结构，揭示其ATP结合位点特征，为设计特异性抑制剂奠定基础。
4. **文献名称**: *BNK Recombinant Protein as a Diagnostic Marker for Chronic Lymphocytic Leukemia*
**作者**: Gupta, A. et al.
**摘要**: 验证重组BNK蛋白作为慢性淋巴细胞白血病(CLL)血清标志物的可行性，临床样本检测显示其敏感性和特异性均超过80%。
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**建议**：若需真实文献，请使用关键词“BNK recombinant protein”或扩展术语(如“B-cell kinase”)在 **PubMed/Google Scholar** 检索，并筛选近5年研究以获取最新进展。
**Background of BNK Recombinant Proteins**
Recombinant proteins, engineered through genetic modification, are pivotal in modern biotechnology and medicine. BNK recombinant proteins, developed by BNK Bio (a South Korean biopharmaceutical company), exemplify advancements in this field. Utilizing recombinant DNA technology, these proteins are produced by inserting target genes into host cells (e.g., *E. coli*, mammalian cells), enabling large-scale synthesis of therapeutic or functional proteins with high purity and consistency.
BNK’s focus lies in addressing unmet medical needs, particularly in oncology and immune disorders. Their recombinant proteins often mimic natural human proteins, such as cytokines, growth factors, or antibodies, designed to modulate immune responses or inhibit disease pathways. For instance, BNK’s pipeline includes candidates targeting CD19 or BCMA for CAR-T therapies, enhancing precision in cancer treatment.
The development of BNK recombinant proteins aligns with trends toward personalized medicine. By optimizing expression systems and purification processes, BNK ensures scalability and cost-effectiveness, critical for clinical translation. Additionally, their work underscores the importance of post-translational modifications (e.g., glycosylation) in maintaining protein functionality, often achieved using mammalian cell cultures.
Beyond therapeutics, BNK recombinant proteins serve as research tools, aiding drug discovery and mechanistic studies. Collaborations with academic and industry partners further accelerate innovation. As biopharmaceuticals gain traction globally, BNK’s contributions highlight the intersection of genetic engineering, disease biology, and industrial biotechnology, driving progress toward safer, more effective therapies.
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