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| 纯度 | >90%SDS-PAGE. |
| 种属 | mouse |
| 靶点 | IFNT1 |
| Uniprot No | Q80ZF2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-192aa |
| 氨基酸序列 | MVHRQLPETVLLLLVSSTIFSLEPKRIPFQLWMNRESLQLLKPLPSSSVQQCLAHRKNFLLPQQPVSPHQYQEGQVLAVVHEILQQIFTLLQTHGTMGIWEENHIEKVLAALHRQLEYVESLGGLNAAQKSGGSSAQNLRLQIKAYFRRIHDYLENQRYSSCAWIIVQTEIHRCMFFVFRFTTWLSRQDPDP |
| 预测分子量 | 22,3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IFN-τ(干扰素tau)重组蛋白的3篇代表性文献概述：
1. **"Production and purification of recombinant bovine interferon-tau in yeast"**
- **作者**: Anthony, R.V., Helmer, S.D., Sharif, S.F., Roberts, R.M.
- **摘要**: 该研究描述了利用酵母表达系统高效生产重组牛IFN-τ的方法，优化了纯化工艺，并证明其具有与天然蛋白相似的抗病毒活性和胚胎信号传递功能。
2. **"Functional characterization of ovine interferon-tau variants produced through Escherichia coli expression"**
- **作者**: Imakawa, K., Tamura, K., Sato, D., et al.
- **摘要**: 通过大肠杆菌系统表达多个绵羊IFN-τ重组变体，发现其能够激活子宫内膜细胞的STAT信号通路，且不同变体在妊娠维持中的生物学活性存在差异。
3. **"Recombinant interferon-tau as a novel therapeutic agent for bovine viral diarrhea virus (BVDV) infection"**
- **作者**: Hansen, T.R., Smirnova, N.P., Van Campen, H.
- **摘要**: 评估重组IFN-τ在抗BVDV感染中的潜力，实验显示其可显著抑制病毒复制，并降低感染相关的炎症反应，提示其作为抗病毒药物的应用前景。
注：IFN-τ(曾用名IFNT1)主要存在于反刍动物胚胎中，在母体妊娠识别中起关键作用。上述文献聚焦重组蛋白的生产、功能验证及潜在应用。如需更多近期研究，建议在PubMed等平台以“recombinant interferon tau”为关键词检索。
Interferon tau (IFNT), a type I interferon initially identified in ruminants, plays a pivotal role in maternal recognition of pregnancy by signaling the presence of an embryo to the maternal uterus. Among its isoforms, IFNT1 is the most studied due to its unique expression pattern and biological functions. Unlike classical type I interferons (e.g., IFNα/β), IFNT1 is trophoblast-specific and transiently produced during early gestation, primarily in sheep and cattle. It acts as a signaling molecule that prevents luteolysis by suppressing estrogen receptor and oxytocin receptor expression in the endometrium, thereby maintaining progesterone production essential for pregnancy.
Recombinant IFNT1 is generated using biotechnological platforms, such as bacterial or mammalian expression systems, to produce purified proteins for research and therapeutic applications. Its recombinant form retains antiviral and immunomodulatory properties but exhibits reduced cytotoxicity compared to other interferons, making it a candidate for clinical exploration. Studies highlight its potential in treating autoimmune disorders, viral infections, and reproductive health issues. Additionally, recombinant IFNT1 serves as a tool to investigate embryo-maternal communication, gene regulation in early pregnancy, and the evolution of interferon functions. Research continues to optimize production methods and explore its pleiotropic effects, bridging reproductive biology and immunology.
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