关键信息
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基因名
IL-21R
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简介
IL-21R protein, a receptor for interleukin-21, forms a heterodimer with the common gamma subunit and associates with Janus kinase 1 (JAK1). These interactions are pivotal for transducing the cellular responses initiated by interleukin-21, regulating immune processes and inflammatory pathways. IL-21R Protein, Human (HEK293, Fc) is the recombinant human-derived IL-21R protein, expressed by HEK293 , with C-hFc labeled tag.
- 应用
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别名
IL-21 receptor; IL-21R; CD360; NILR
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HBE5
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表达区间
C20-P236
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蛋白长度
Partial
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分子量
60-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Interleukin-21 receptor (IL-21R) is a critical component of the immune system, primarily functioning as a receptor for interleukin-21 (IL-21), a cytokine produced by T follicular helper cells. The IL-21/IL-21R signaling pathway plays a significant role in the regulation of various immune responses, including B cell maturation, proliferation, and antibody production, which are vital for effective humoral immunity. Dysregulation of this pathway has been linked to numerous autoimmune diseases, malignancies, and infections, highlighting its potential as a therapeutic target. Research into IL-21R has intensified in recent years, focusing on its structural biology, signaling mechanisms, and potential as an intervention point for diseases characterized by immune system dysfunction. The development of recombinant IL-21R proteins is particularly noteworthy, as these proteins can be used as tools for elucidating the receptor's biology, exploring the nuances of IL-21 signaling, and ultimately assessing their therapeutic efficacy in treating various immune-related conditions. Engineering soluble forms of IL-21R has facilitated the study of its ligand interactions and downstream signaling pathways, opening new avenues for understanding immune regulation and developing innovative treatments. Overall, the exploration of IL-21R and its signaling pathways represents a promising area of research with implications for improving therapeutic strategies in immunology.
