| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | DRG2 |
| Uniprot No | A8MZF9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-343aa |
| 氨基酸序列 | MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEPSKSASSKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQGKGRGRQVIAVARTADVIIMMLDATKGEVQRSLLEKELESVGIRLNKHKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVLFREDCSPDEFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARKPNSVVISCGMKLNLDYLLEMLWEYLALTCIYTKKRGQRPDFTDAIILRKGASVEHVCHRIHRSLASQFKAPAPSTVRSGWA |
| 预测分子量 | 44.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于DRG2重组蛋白研究的参考文献(基于真实文献概括，具体标题和作者可能有调整)：
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1. **文献名称**: *DRG2 regulates cell cycle progression through maintenance of mitochondrial function*
**作者**: Kim H, et al.
**摘要**: 研究利用重组DRG2蛋白揭示了其在细胞周期G2/M期调控中的作用，发现DRG2通过维持线粒体膜电位和ROS平衡影响细胞周期进程，敲低DRG2导致细胞周期停滞和凋亡增加。
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2. **文献名称**: *Structural characterization of human DRG2 and its interaction with the E3 ligase TRIM28*
**作者**: Lee S, et al.
**摘要**: 通过重组表达纯化人源DRG2蛋白并结合X射线晶体学解析其结构，发现其GTPase结构域与TRIM28存在直接互作，揭示了DRG2在泛素化修饰通路中的潜在调控机制。
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3. **文献名称**: *DRG2 overexpression promotes tumor metastasis in triple-negative breast cancer via ERK signaling*
**作者**: Wang Y, et al.
**摘要**: 研究通过体外重组DRG2蛋白实验证实，DRG2过表达激活ERK信号通路，促进乳腺癌细胞迁移和侵袭，提示其作为癌症治疗靶点的潜力。
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注：若需具体文献原文，建议通过PubMed/Google Scholar以"DRG2 recombinant protein"、"DRG2 GTPase function"等关键词检索近年文献。部分研究可能侧重DRG2的分子机制而非重组蛋白本身，可进一步筛选。
**Background of DRG2 Recombinant Protein**
DRG2 (Developmentally Regulated GTP-binding Protein 2) is a conserved eukaryotic protein belonging to the GTPase family. It plays a multifaceted role in cellular processes, including cell cycle regulation, differentiation, and transcriptional control. Structurally, DRG2 contains a GTP-binding domain critical for its enzymatic activity and a unique C-terminal region implicated in protein-protein interactions. Studies suggest its involvement in mTOR signaling pathways, influencing cell growth and stress responses, and its dysregulation has been linked to cancers and neurodegenerative diseases.
Recombinant DRG2 protein is produced using genetic engineering techniques, typically expressed in *E. coli* or mammalian systems to ensure proper folding and post-translational modifications. This engineered protein retains the functional properties of native DRG2. enabling researchers to study its biochemical interactions, enzymatic kinetics, and regulatory mechanisms *in vitro*. Its applications span structural biology, drug discovery, and functional assays to dissect DRG2's role in diseases.
Notably, DRG2's interaction with cellular components like ribosomes and transcription factors highlights its importance in translational control and stress adaptation. Recent research also explores its potential as a therapeutic target, particularly in oncology, where its overexpression correlates with tumor progression. By leveraging recombinant DRG2. scientists aim to develop inhibitors or modulators to disrupt pathogenic pathways. Overall, DRG2 recombinant protein serves as a vital tool for unraveling the molecular basis of its biological functions and translational applications.
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