| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | STAB1 |
| Uniprot No | Q9NY15 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2319-2462aa |
| 氨基酸序列 | STCNGKLLDVLAATANFSTFYGMLLGYANATQRGLDFLDFLDDELTYKTLFVPVNEGFVDNMTLSGPDLELHASNATLLSANASQGKLLPAHSGLSLIISDAGPDNSSWAPVAPGTVVVSRIIVWDIMAFNGIIHALASPLLAP |
| 预测分子量 | 22.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于STAB1重组蛋白的3篇参考文献及其摘要内容(文献信息为模拟示例，供参考)：
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1. **标题**：*Recombinant Stabilin-1 mediates clearance of extracellular matrix in lymphatic endothelial cells*
**作者**：Smith A, et al.
**摘要**：研究利用HEK293细胞表达重组STAB1蛋白，验证其通过结合透明质酸和硫酸软骨素促进细胞外基质的吞噬作用，揭示了其在淋巴管重塑中的潜在机制。
2. **标题**：*Structural and functional analysis of the scavenger receptor STAB1 in angiogenesis*
**作者**：Li H, et al.
**摘要**：通过昆虫细胞系统表达STAB1胞外域重组蛋白，解析其晶体结构，发现其与VEGF受体互作调控血管生成，为抗肿瘤治疗提供新靶点。
3. **标题**：*STAB1 recombinant protein attenuates liver fibrosis via modulating macrophage phagocytosis*
**作者**：Garcia R, et al.
**摘要**：在大肠杆菌中表达功能性STAB1重组蛋白，证明其通过增强巨噬细胞对凋亡细胞的清除能力，减轻小鼠肝纤维化模型中的组织损伤。
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注：以上文献信息为领域典型研究方向模拟生成，实际文献需通过学术数据库(如PubMed/Google Scholar)检索确认。
**Background of STAB1 Recombinant Protein**
Stabilin-1 (STAB1), also known as FEEL-1 or CLEVER-1. is a large transmembrane glycoprotein belonging to the scavenger receptor family. It is predominantly expressed in endothelial cells, macrophages, and sinusoidal lining cells, where it plays critical roles in immune regulation, cellular adhesion, and clearance of extracellular components. Structurally, STAB1 contains multiple functional domains, including EGF-like repeats, Fasciclin domains, and a hyaluronan-binding domain, enabling interactions with diverse ligands such as hyaluronic acid, advanced glycation end products (AGEs), and apoptotic cells.
STAB1 is implicated in modulating immune tolerance, angiogenesis, and tissue homeostasis. It contributes to phagocytic clearance of cellular debris, regulates leukocyte trafficking, and suppresses inflammatory responses in certain contexts. Dysregulation of STAB1 has been associated with pathological conditions, including atherosclerosis, cancer metastasis, and chronic inflammatory diseases. In tumors, STAB1-expressing macrophages often exhibit immunosuppressive properties, linking it to tumor microenvironment remodeling.
Recombinant STAB1 protein is engineered in vitro using expression systems (e.g., mammalian or insect cells) to produce purified, bioactive forms of the protein. This enables functional studies, such as ligand-binding assays, signaling pathway analysis, and exploration of its role in cellular communication. Researchers utilize STAB1 recombinant proteins to investigate its therapeutic potential, including targeting STAB1 for immunomodulation or designing inhibitors to block pathogenic interactions. Its dual role in homeostasis and disease makes STAB1 a compelling subject for biomedical research and drug development.
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