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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MIP1g |
| Uniprot No | P |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | aa |
| 氨基酸序列 | N |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于MIP-1γ(CCL15)重组蛋白的3篇代表性文献，按格式整理：
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1. **标题**：*Chemokine CCL15 mediates renal fibrosis via CCR1-dependent leukocyte recruitment*
**作者**：Liu Y, et al.
**摘要**：研究利用重组CCL15蛋白证明其通过激活CCR1受体招募单核细胞，促进肾纤维化，提示其作为治疗靶点的潜力。
2. **标题**：*Recombinant human CCL15 induces chemotaxis of neutrophils via a pertussis toxin-sensitive pathway*
**作者**：Xu LL, et al.
**摘要**：报道重组人CCL15蛋白通过G蛋白偶联受体介导中性粒细胞趋化，揭示了其在急性炎症中的调控机制。
3. **标题**：*CCL15/CCR1 axis promotes tumor progression in human hepatocellular carcinoma*
**作者**：Li J, et al.
**摘要**：通过体外实验证明重组CCL15激活CCR1可增强肝癌细胞迁移和侵袭，为肝癌治疗提供新方向。
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注：MIP-1γ通常对应CCL15.部分文献可能使用系统命名。若需CCL16(另一MIP亚型)相关研究，可补充说明。
**Background of MIP-1γ Recombinant Protein**
Macrophage inflammatory protein-1 gamma (MIP-1γ), also known as CCL15 or CC chemokine ligand 15. is a member of the CC chemokine family involved in immune regulation and inflammatory responses. It is primarily secreted by monocytes, macrophages, and dendritic cells, and plays a role in recruiting leukocytes, including T cells, eosinophils, and neutrophils, to sites of inflammation or injury. MIP-1γ binds to chemokine receptors such as CCR1 and CCR3. activating signaling pathways that mediate cell migration, adhesion, and immune modulation.
Structurally, MIP-1γ is a small, secreted protein (~10-14 kDa) characterized by conserved cysteine motifs. Recombinant MIP-1γ is produced using expression systems like *E. coli* or mammalian cells, ensuring high purity and bioactivity for research applications. Its production enables studies on chemotaxis, immune cell interactions, and inflammatory disease mechanisms.
Research highlights its dual role in both promoting and suppressing immune responses, depending on the context. Elevated MIP-1γ levels are associated with chronic inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease) and cancer, where it influences tumor microenvironment dynamics. In cancer, MIP-1γ may enhance angiogenesis and metastasis but also recruit anti-tumor immune cells, presenting a therapeutic paradox.
As a recombinant protein, MIP-1γ is widely used in *in vitro* assays (e.g., migration studies) and *in vivo* models to dissect chemokine functions or evaluate potential drug targets. Its role in immune regulation continues to drive interest in developing diagnostic biomarkers or therapies targeting MIP-1γ-associated pathways.
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