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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IL1z |
| Uniprot No | P |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | aa |
| 氨基酸序列 | full |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IL-1ζ(IL-1Z)重组蛋白的3篇参考文献示例(注：IL-1ζ研究较少，部分文献可能与IL-1家族相关或名称存在差异)：
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1. **文献名称**：*"Characterization of IL-1ζ, a novel member of the interleukin-1 family"*
**作者**：Smith A, et al.
**摘要**：本研究首次报道了IL-1ζ作为IL-1家族新成员的发现，通过重组蛋白技术表达并纯化了人源IL-1ζ，证实其与IL-1受体结合的能力，并发现其在炎症反应中可能通过调控NF-κB通路发挥作用。
2. **文献名称**：*"Recombinant IL-1ζ induces cytokine production in macrophages via TLR4 signaling"*
**作者**：Zhang L, et al.
**摘要**：作者利用大肠杆菌系统成功表达IL-1ζ重组蛋白，证明其可激活巨噬细胞分泌TNF-α和IL-6.且该效应依赖于TLR4受体，提示IL-1ζ在先天免疫中的潜在功能。
3. **文献名称**：*"Structural and functional analysis of IL-1ζ in autoimmune disease models"*
**作者**：Wang Y, et al.
**摘要**：通过晶体学解析了IL-1ζ重组蛋白的三维结构，并在类风湿性关节炎小鼠模型中验证其促炎作用，发现IL-1ζ中和抗体可显著减轻关节炎症。
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**说明**：
- IL-1ζ(IL-1Z)属于IL-1超家族，但研究相对有限，以上文献为示例性质，实际文献需通过PubMed或专业数据库检索确认。
- 若需具体文献，建议以关键词“IL1Z recombinant protein”或“Interleukin 1 zeta”在 **PubMed**(https://pubmed.ncbi.nlm.nih.gov)中进一步筛选。
**Background of IL-1z Recombinant Protein**
The IL-1 family of cytokines plays a central role in regulating immune and inflammatory responses. IL-1z (Interleukin-1 zeta), a less characterized member, is hypothesized to function as a modulator within this signaling network. Like other IL-1 family proteins, IL-1z is thought to interact with specific receptors, such as IL-1R1 or IL-1R2. to either activate or inhibit downstream inflammatory pathways. Its exact biological role remains under investigation, but studies suggest it may act as a decoy receptor or competitive antagonist, dampening excessive IL-1-driven inflammation—a mechanism critical in conditions like autoimmune diseases, sepsis, or chronic inflammation.
Recombinant IL-1z is produced using biotechnological platforms, such as *E. coli* or mammalian expression systems, to ensure proper folding and post-translational modifications. This engineered protein retains the functional domains required for receptor binding, enabling researchers to study its interaction with IL-1 signaling components *in vitro* and *in vivo*. Its applications span basic research—elucidating IL-1 pathway dynamics—to preclinical drug development, where it serves as a candidate for therapeutic intervention in IL-1-associated disorders.
Interest in IL-1z also stems from the clinical success of IL-1-targeting biologics (e.g., anakinra, canakinumab), highlighting the therapeutic potential of modulating this pathway. By providing a tool to selectively regulate IL-1 activity, recombinant IL-1z contributes to understanding immune homeostasis and designing next-generation anti-inflammatory therapies. Further studies are needed to clarify its physiological relevance and translational utility.
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