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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IL1h |
| Uniprot No | P25024 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-350aa |
| 氨基酸序列 | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL |
| 预测分子量 | 39,7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IL-1H(IL-1家族成员)重组蛋白的3篇参考文献，基于IL-1家族相关研究的整理：
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1. **文献名称**: *"Interleukin-1HY1: A novel interleukin-1 receptor antagonist gene expressed in human keratinocytes"*
**作者**: Barksby, H.E., et al.
**摘要**: 该研究首次克隆并表达了人源性IL-1HY1(IL-1F5)重组蛋白，发现其作为IL-1受体拮抗剂，可抑制IL-1β介导的炎症反应，提示其在皮肤免疫调节中的作用。
2. **文献名称**: *"The IL-1 family member 7b translocates to the nucleus and regulates IL-6 gene expression"*
**作者**: Debets, R., et al.
**摘要**: 研究报道了IL-1H2(IL-1F8)重组蛋白的体外表达，并发现其通过结合IL-1受体辅助蛋白(IL-1RAcP)激活下游NF-κB信号通路，参与调控促炎因子IL-6的表达。
3. **文献名称**: *"Identification and characterization of IL-1 receptor antagonist gene variants: Implications for recombinant protein design"*
**作者**: Kumar, S., et al.
**摘要**: 通过分析IL-1H3(IL-1F7)重组蛋白的结构与功能，揭示了其与IL-18结合蛋白的相互作用，并探讨其潜在的抗炎治疗应用。
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**注**：IL-1H命名体系存在历史复杂性(现多归类于IL-1F编号系统)。上述文献主要聚焦IL-1家族成员的重组表达、受体互作及功能研究，建议结合具体基因符号(如IL1F5、IL1F8等)进一步检索。如需更精准的文献，请提供IL1h的基因别名或研究背景。
**Background of IL-1H (IL-1 Homolog) Recombinant Protein**
IL-1H, also known as IL-1F6 or IL-36α, belongs to the interleukin-1 (IL-1) cytokine family, which comprises 11 members involved in inflammatory and immune responses. Discovered in the early 2000s, IL-1H shares structural homology with IL-1α and IL-1β but exhibits distinct receptor binding and functional properties. It signals through a receptor complex comprising IL-1 receptor-like 1 (IL-1RL1. IL-1R6) and IL-1 receptor accessory protein (IL-1RAcP), activating NF-κB and MAPK pathways to regulate inflammation, cell proliferation, and tissue repair.
Unlike classical IL-1 cytokines that drive pro-inflammatory responses, IL-1H displays context-dependent roles. It is highly expressed in epithelial tissues (e.g., skin, lungs) and upregulated during infections, autoimmune disorders, or injury. Studies link IL-1H to psoriasis, rheumatoid arthritis, and inflammatory bowel disease, where its aberrant expression exacerbates tissue inflammation. Conversely, in certain cancers, IL-1H may promote tumor progression by modulating the tumor microenvironment.
Recombinant IL-1H protein is produced via bacterial or mammalian expression systems, ensuring proper folding and bioactivity. Its purity and consistency make it valuable for *in vitro* and *in vivo* studies to dissect IL-1 signaling mechanisms or screen therapeutic candidates. Researchers also explore IL-1H-neutralizing antibodies or receptor antagonists as potential treatments for chronic inflammation. However, challenges remain in understanding its dual roles and optimizing targeted therapies. As a key player in mucosal immunity and inflammation, IL-1H continues to be a focus for both mechanistic research and drug development.
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