| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ACVR1C |
| Uniprot No | Q8NER5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-493aa |
| 氨基酸序列 | MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASV MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLP TASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPN VEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEI VGKGRFGEVWHGRWCGEDVAVKIFSSRDERYWFREAEIYQTVMLRHENIL GFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTMAGMIKLALSIA SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWE IARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQS CEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA |
| 预测分子量 | 80 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
1. **"ACVR1C (ALK7) Recombinant Protein Promotes Brown Adipocyte Differentiation via Activation of SMAD2/3 Signaling"**
*Authors: Zhang Y, et al.*
摘要：研究利用重组ACVR1C蛋白处理前脂肪细胞，证实其通过SMAD2/3通路促进棕色脂肪细胞分化，为代谢疾病治疗提供潜在靶点。
2. **"Functional Characterization of Recombinant ACVR1C in TGF-β Superfamily Ligand Binding"**
*Authors: Thompson R, et al.*
摘要：通过体外结合实验分析重组ACVR1C蛋白与Activin B、Nodal等配体的相互作用，揭示其特异性结合能力及信号激活机制。
3. **"ACVR1C Recombinant Protein Attenuates Fibrosis in a Mouse Model of Pulmonary Injury"**
*Authors: Lee S, et al.*
摘要：在小鼠肺纤维化模型中，重组ACVR1C蛋白通过抑制过度SMAD信号通路，显著减少胶原沉积和炎症反应。
4. **"Structural Insights into ACVR1C Activation by Recombinant Protein Crystallography"**
*Authors: Martinez D, et al.*
摘要：解析重组ACVR1C胞外域的晶体结构，揭示其配体结合区域构象变化，为设计靶向药物提供结构基础。
注：以上文献信息为示例性概括，实际文献需根据具体研究内容检索确认。
ACVR1C, also known as activin receptor-like kinase 7 (ALK7), is a transmembrane serine/threonine kinase receptor belonging to the TGF-β (transforming growth factor-beta) superfamily. It plays a critical role in mediating cellular responses to ligands such as activins, growth differentiation factors (GDFs), and nodal. These ligands regulate diverse biological processes, including cell proliferation, differentiation, apoptosis, and metabolic homeostasis. ACVR1C is particularly notable for its involvement in signaling pathways that influence tissue development, immune regulation, and energy metabolism. Dysregulation of ACVR1C has been linked to pathologies like fibrosis, cancer, and metabolic disorders, making it a target for therapeutic research.
Recombinant ACVR1C protein is engineered in vitro using expression systems (e.g., mammalian, insect, or bacterial cells) to produce soluble, functional forms of the receptor or its extracellular domain. This enables researchers to study its structure, ligand-binding properties, and downstream signaling mechanisms without interference from membrane-associated complexities. Recombinant ACVR1C is often fused with tags (e.g., Fc or His tags) to facilitate purification and detection. Its applications include ligand-receptor interaction assays, high-throughput drug screening, and structural studies (e.g., X-ray crystallography). Additionally, it serves as a tool to investigate ACVR1C’s role in diseases, such as its dual pro- or anti-tumor effects in different cancers or its impact on adipocyte differentiation in metabolic syndromes. Recent studies also explore its potential as a therapeutic target, particularly in metabolic and fibrotic diseases. By modulating ACVR1C activity via recombinant proteins or inhibitors, researchers aim to develop treatments that restore disrupted signaling pathways. Overall, recombinant ACVR1C is pivotal for advancing both basic science and translational research in cellular signaling and disease mechanisms.
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