| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LRRN1 |
| Uniprot No | Q6UXK5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 26-631aa |
| 氨基酸序列 | SIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTLLDGTQVLKIYVKQTESHSILVSWKVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVNVTTKNAAFAVDISDQETSTA |
| 预测分子量 | 84.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于LRRN1重组蛋白的3篇参考文献示例(注：文献信息为模拟示例，实际引用需检索真实数据库)：
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1. **文献名称**: *LRRN1重组蛋白的体外表达及在神经突触粘附中的作用*
**作者**: Smith A, et al.
**摘要**: 研究通过大肠杆菌系统成功表达并纯化LRRN1重组蛋白，证实其能够促进神经元细胞间的粘附，提示其在神经突触形成中的潜在功能。
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2. **文献名称**: *LRRN1胞外结构域重组蛋白的晶体结构解析*
**作者**: Chen L, et al.
**摘要**: 利用哺乳动物细胞表达系统获得LRRN1胞外结构域重组蛋白，并通过X射线晶体学解析其三维结构，揭示其富含亮氨酸重复序列(LRR)的特征性折叠模式。
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3. **文献名称**: *LRRN1重组蛋白通过调控Wnt信号通路抑制肿瘤转移*
**作者**: Wang Y, et al.
**摘要**: 研究发现，重组LRRN1蛋白能够结合Wnt受体并抑制下游信号通路，显著降低癌细胞侵袭能力，为靶向LRRN1的抗肿瘤治疗提供理论依据。
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**提示**：实际文献需通过PubMed、Google Scholar等平台检索关键词“LRRN1 recombinant protein”或“LRRN1 ectodomain expression”，筛选涉及重组蛋白表达、功能或机制的研究。
**Background of LRRN1 Recombinant Protein**
LRRN1 (Leucine-Rich Repeat Neuronal Protein 1) is a member of the leucine-rich repeat (LRR) superfamily, characterized by repetitive structural motifs involved in protein-protein interactions, signaling, and cellular adhesion. Predominantly expressed in the nervous system, LRRN1 is implicated in neural development, synaptic plasticity, and neuronal connectivity. Its structural domains, including LRRs and immunoglobulin-like regions, suggest roles in extracellular matrix interactions or receptor-ligand binding, though its precise molecular mechanisms remain under investigation.
Recombinant LRRN1 protein is engineered using biotechnological methods (e.g., expression in *E. coli* or mammalian cell lines*) to produce purified, functional protein for research. This allows controlled study of LRRN1’s biological activities, such as its potential involvement in neurodevelopmental disorders, neurodegenerative diseases, or cancer. For instance, altered LRRN1 expression has been observed in glioblastoma and neuroblastoma, hinting at possible oncogenic or tumor-suppressive roles.
In biomedical research, recombinant LRRN1 serves as a tool to explore its interactions with binding partners (e.g., receptors, growth factors) or to develop antibodies for diagnostic assays. Its application extends to drug discovery, particularly in targeting pathways linked to neural regeneration or cancer progression. Despite its emerging significance, further studies are needed to fully elucidate LRRN1’s physiological and pathological roles, making recombinant protein tools critical for advancing this field.
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