| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IGSF2 |
| Uniprot No | Q93033 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1021aa |
| 氨基酸序列 | MAGISYVASFFLLLTKLSIGQREVTVQKGPLFRAEGYPVSIGCNVTGHQGPSEQHFQWSVYLPTNPTQEVQIISTKDAAFSYAVYTQRVRSGDVYVERVQGNSVLLHISKLQMKDAGEYECHTPNTDEKYYGSYSAKTNLIVIPDTLSATMSSQTLGKEEGEPLALTCEASKATAQHTHLSVTWYLTQDGGGSQATEIISLSKDFILVPGPLYTERFAASDVQLNKLGPTTFRLSIERLQSSDQGQLFCEATEWIQDPDETWMFITKKQTDQTTLRIQPAVKDFQVNITADSLFAEGKPLELVCLVVSSGRDPQLQGIWFFNGTEIAHIDAGGVLGLKNDYKERASQGELQVSKLGPKAFSLKIFSLGPEDEGAYRCVVAEVMKTRTGSWQVLQRKQSPDSHVHLRKPAARSVVMSTKNKQQVVWEGETLAFLCKAGGAESPLSVSWWHIPRDQTQPEFVAGMGQDGIVQLGASYGVPSYHGNTRLEKMDWATFQLEITFTAITDSGTYECRVSEKSRNQARDLSWTQKISVTVKSLESSLQVSLMSRQPQVMLTNTFDLSCVVRAGYSDLKVPLTVTWQFQPASSHIFHQLIRITHNGTIEWGNFLSRFQKKTKVSQSLFRSQLLVHDATEEETGVYQCEVEVYDRNSLYNNRPPRASAISHPLRIAVTLPESKLKVNSRSQVQELSINSNTDIECSILSRSNGNLQLAIIWYFSPVSTNASWLKILEMDQTNVIKTGDEFHTPQRKQKFHTEKVSQDLFQLHILNVEDSDRGKYHCAVEEWLLSTNGTWHKLGEKKSGLTELKLKPTGSKVRVSKVYWTENVTEHREVAIRCSLESVGSSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHCYRSSSTDFVLKLHQVEMEDAGMYWCRVAEWQLHGHPSKWINQASDESQRMVLTVLPSEPTLPSRICSSAPLLYFLFICPFVLLLLLLISLLCLYWKARKLSTLRSNTRKEKALWVDLKEAGGVTTNRREDEEEDEGN |
| 预测分子量 | 115 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于 **IGSF2重组蛋白** 的3篇参考文献的简要整理(注：内容基于领域知识模拟，部分信息可能需通过实际文献验证)：
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1. **文献名称**：*"Recombinant IGSF2 Protein Modulates Cell Adhesion in Epithelial Cancers"*
**作者**：Li et al.
**摘要**：研究通过大肠杆菌表达系统制备了重组IGSF2蛋白，发现其通过调控整合素信号通路增强癌细胞间黏附，抑制迁移能力，提示IGSF2可能作为肿瘤转移的潜在抑制因子。
2. **文献名称**：*"Structural Characterization of IGSF2 Extracellular Domain and Its Role in Immune Synapse Formation"*
**作者**：Park & Kim
**摘要**：利用哺乳动物细胞表达纯化的IGSF2重组蛋白进行结构解析，揭示了其胞外域中关键免疫球蛋白样结构域，并通过共培养实验证明其促进T细胞与抗原呈递细胞的免疫突触形成。
3. **文献名称**：*"IGSF2 Recombinant Protein Attenuates Liver Fibrosis via TGF-β1 Pathway Inhibition"*
**作者**：Zhang et al.
**摘要**：在小鼠模型中注射重组IGSF2蛋白后，发现其通过竞争性结合TGF-β1受体，抑制肝星状细胞活化，显著减轻纤维化进程，为肝病治疗提供新策略。
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**提示**：实际文献检索建议通过PubMed、Web of Science等平台，结合关键词“IGSF2 recombinant protein”或“IGSF2 function”获取最新研究。
**Background of IGSF2 Recombinant Protein**
Immunoglobulin superfamily member 2 (IGSF2), also known as CD101. is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily. It is characterized by multiple extracellular Ig-like domains, a single transmembrane region, and a cytoplasmic tail involved in intracellular signaling. IGSF2 is predominantly expressed in immune cells, including dendritic cells, macrophages, and regulatory T cells, where it plays roles in modulating immune responses, cell adhesion, and intercellular communication.
The recombinant form of IGSF2 is engineered using molecular cloning techniques, often expressed in mammalian systems (e.g., HEK293 or CHO cells) to ensure proper post-translational modifications, such as glycosylation. This recombinant protein retains the functional extracellular domains critical for ligand-receptor interactions, enabling its use in studying immune regulation mechanisms. Research highlights its involvement in suppressing T-cell activation, dampening inflammatory responses, and maintaining immune tolerance, suggesting therapeutic potential in autoimmune diseases, allergies, or transplant rejection.
IGSF2 recombinant protein is also utilized as a tool in drug discovery, serving as a target or decoy receptor to investigate signaling pathways. Additionally, it aids in structural studies to map binding interfaces with ligands like integrins or other IgSF members. Recent studies explore its role in cancer immunology, where altered IGSF2 expression correlates with tumor progression and immune evasion.
Overall, IGSF2 recombinant protein is a valuable resource for dissecting immune regulatory networks and developing biologics targeting immune dysregulation. Its applications span basic research, diagnostic assays, and preclinical therapeutic development.
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