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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | GDF10 |
| Uniprot No | P55107 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 369-478aa |
| 氨基酸序列 | QWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR |
| 预测分子量 | 16.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于GDF10重组蛋白的3篇代表性文献示例(注：文献信息为模拟内容，供参考)：
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1. **文献名称**: *GDF10 promotes axonal regeneration through TGF-β signaling*
**作者**: Smith A, et al.
**摘要**: 该研究报道了重组GDF10蛋白在神经损伤模型中的促轴突再生作用，通过激活Smad通路增强神经元存活和突触重塑。
2. **文献名称**: *Recombinant GDF10 enhances osteoblast differentiation in vitro*
**作者**: Chen L, et al.
**摘要**: 研究利用大肠杆菌表达系统制备重组GDF10蛋白，证实其通过BMP信号通路刺激成骨细胞分化，可能用于骨质疏松治疗。
3. **文献名称**: *GDF10 recombinant protein mitigates muscle fibrosis in dystrophic mice*
**作者**: Tanaka K, et al.
**摘要**: 通过腺病毒载体递送重组GDF10至肌肉萎缩模型小鼠，结果显示其显著减少纤维化并促进肌卫星细胞活化。
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(注：实际文献需通过PubMed、Google Scholar等平台以“GDF10 recombinant protein”为关键词检索获取。)
**Background of GDF10 Recombinant Protein**
GDF10 (Growth Differentiation Factor 10), also known as bone morphogenetic protein 3b (BMP3b), is a member of the transforming growth factor-beta (TGF-β) superfamily. It plays a critical role in regulating cellular processes such as tissue repair, differentiation, and development. Initially identified for its involvement in skeletal and neural development, GDF10 has garnered attention for its diverse biological functions. Studies suggest its involvement in neuroprotection, metabolic regulation, and tissue remodeling, particularly in contexts like neurodegenerative diseases, obesity, and wound healing.
GDF10 is synthesized as a precursor protein, which undergoes proteolytic cleavage to release the mature, biologically active dimer. Recombinant GDF10 is produced using expression systems like *E. coli* or mammalian cells, ensuring high purity and bioactivity for research and therapeutic applications. Its recombinant form enables precise study of its mechanisms, including interactions with cell surface receptors (e.g., activin receptor-like kinases) and downstream signaling pathways, such as SMAD-dependent cascades.
Recent research highlights GDF10's therapeutic potential. In neurodegenerative disorders like Alzheimer’s disease, it may promote neuronal survival and synaptic plasticity. In metabolic syndromes, it modulates adipogenesis and insulin sensitivity. Additionally, GDF10 influences bone remodeling and fibrosis resolution, making it a candidate for treating osteoporosis or organ fibrosis. Despite progress, further studies are needed to fully elucidate its pleiotropic roles and optimize clinical translation. Overall, GDF10 recombinant protein serves as a valuable tool for both basic research and drug development.
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