| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | NPTXR |
| Uniprot No | O95502 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-500aa |
| 氨基酸序列 | MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGADNASVASGAAASPGPQRSLSALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLSAAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA |
| 预测分子量 | 52,8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇涉及NPTXR(Neuronal Pentraxin Receptor)重组蛋白相关研究的文献示例(注：文献标题与作者为虚构模拟，实际文献需通过数据库验证)：
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1. **标题**: *NPTXR recombinant protein promotes synaptic plasticity in vitro*
**作者**: Xiao M., et al.
**摘要**: 本研究成功在大肠杆菌中表达并纯化了功能性NPTXR重组蛋白，发现其能通过激活突触后AMPA受体增强海马神经元的突触传递效率，提示其在神经可塑性中的潜在调控作用。
2. **标题**: *Structural characterization of human NPTXR and its interaction with neuronal pentraxins*
**作者**: Sia G.M., et al.
**摘要**: 利用重组NPTXR蛋白进行X射线晶体学分析，揭示了其与配体NP1(Neuronal Pentraxin 1)的结合位点，为理解NPTXR在突触形成和维持中的分子机制提供结构基础。
3. **标题**: *NPTXR recombinant protein as a biomarker in Alzheimer's disease models*
**作者**: Brose N., Otsu S.
**摘要**: 在阿尔茨海默病小鼠模型中，外源性重组NPTXR蛋白被证实可部分逆转突触丢失，并通过抑制Aβ毒性改善认知功能，提示其作为治疗靶点的潜力。
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**注意**：以上文献信息为基于领域知识的模拟概括，实际研究中请通过PubMed、Google Scholar等平台检索关键词“NPTXR recombinant protein”或“Neuronal Pentraxin Receptor expression”以获取真实文献数据，并关注近年发表的研究(如2015年后的论文)。
Neuronal Pentraxin Receptor (NPTXR) is a member of the pentraxin protein family, which plays a critical role in synaptic plasticity, neural connectivity, and central nervous system (CNS) development. Unlike short pentraxins (e.g., C-reactive protein) or long pentraxins (e.g., neuronal pentraxin 1/2), NPTXR is a transmembrane protein localized to postsynaptic membranes. It interacts with presynaptic neuronal pentraxins (NP1 and NP2) to mediate excitatory synapse formation, remodeling, and long-term potentiation (LTP), processes essential for learning and memory.
NPTXR is enriched in glutamatergic synapses and regulates AMPA receptor clustering, influencing synaptic strength and stability. Dysregulation of NPTXR has been implicated in neurodevelopmental disorders (e.g., autism spectrum disorders), neurodegenerative diseases (e.g., Alzheimer’s), and psychiatric conditions, making it a potential biomarker or therapeutic target. Recombinant NPTXR protein, typically produced in mammalian or insect cell systems to ensure proper folding and post-translational modifications, retains functional domains for ligand binding and oligomerization. It is widely used in structural studies (e.g., crystallography), in vitro synapse reconstitution assays, and drug screening platforms. Recent research also explores its extracellular role in mediating synaptic pruning and neuroinflammation. The recombinant form enables precise investigation of NPTXR’s molecular mechanisms, offering insights into synaptic pathology and strategies to restore neural network integrity in disease models.
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