首页 / 产品 / 蛋白 / 细胞因子、趋化因子与生长因子
| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | NRG3 |
| Uniprot No | P56975 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 282-342aa |
| 氨基酸序列 | ERSEHFKPCR DKDLAYCLND GECFVIETLT GSHKHCRCKE GYQGVRCDQF LPKTDSILSD P |
| 预测分子量 | 34 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于NRG3重组蛋白的模拟参考文献示例(注：文献为虚构，仅供格式参考)：
1. **文献名称**: Recombinant NRG3 Enhances Cortical Neuron Survival via ErbB4 Activation
**作者**: Chen L, et al.
**摘要**: 研究通过昆虫细胞系统表达重组NRG3.证实其通过结合ErbB4受体促进皮层神经元存活，为神经退行性疾病治疗提供潜在策略。
2. **文献名称**: High-Yield Production of Functional NRG3 in CHO Cells and Its Role in Breast Cancer Migration
**作者**: Martinez R, et al.
**摘要**: 利用CHO细胞高效表达具有生物活性的重组NRG3.并发现其通过MAPK通路增强三阴性乳腺癌细胞迁移，提示其在肿瘤进展中的作用。
3. **文献名称**: Structural and Functional Analysis of NRG3 Isoforms Expressed in E. coli
**作者**: Kim T, et al.
**摘要**: 在大肠杆菌中成功表达两种NRG3剪接变体，通过体外实验验证其差异性的ErbB受体结合能力，为亚型特异性功能研究奠定基础。
4. **文献名称**: Recombinant NRG3 Ameliorates Cognitive Deficits in a Transgenic Alzheimer's Mouse Model
**作者**: Wang Y, et al.
**摘要**: 通过脑内注射重组NRG3蛋白，显著改善AD模型小鼠的突触可塑性和认知功能，机制涉及Aβ清除和神经炎症抑制。
---
建议通过PubMed或Web of Science检索真实文献，关键词：**"recombinant NRG3" OR "neuregulin 3 expression"**。实际研究中，NRG3多聚焦于神经发育、精神疾病及癌症领域。
Neuregulin 3 (NRG3) is a member of the neuregulin family of growth factors, which play critical roles in cell-cell signaling by activating ErbB receptor tyrosine kinases. Discovered in the late 1990s, NRG3 shares structural homology with other neuregulins, particularly an epidermal growth factor (EGF)-like domain essential for receptor binding. However, it distinguishes itself through unique expression patterns and functional specificity. Unlike NRG1 and NRG2. which are broadly involved in neural development, cardiac morphogenesis, and mammary gland differentiation, NRG3 is predominantly expressed in the nervous system, with emerging roles in brain development, synaptic plasticity, and neuronal connectivity.
Recombinant NRG3 proteins are engineered to study its biological functions and therapeutic potential. Produced via mammalian or bacterial expression systems, these proteins typically include the bioactive EGF-like domain to ensure receptor interaction. Purification methods like affinity chromatography ensure high purity and activity. Research highlights NRG3's involvement in regulating cortical interneuron migration, dopaminergic signaling, and gliogenesis. Dysregulation of NRG3 has been linked to neurodevelopmental disorders, including schizophrenia and autism spectrum disorders, as well as cancer progression, where it may influence tumor cell proliferation and metastasis.
In drug discovery, recombinant NRG3 serves as a tool to probe ErbB4 receptor signaling pathways or screen for modulators. Its potential as a therapeutic agent or biomarker remains under exploration, particularly in neurological and oncological contexts. Despite progress, NRG3's full mechanistic landscape and clinical relevance require further investigation to harness its biological significance for targeted therapies.
×
