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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | NRG2 |
| Uniprot No | O14511 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 112-405aa |
| 氨基酸序列 | CYSPSLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKR |
| 预测分子量 | 34.8kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于NRG2重组蛋白的3篇参考文献及其摘要概述：
1. **"Functional characterization of recombinant human neuregulin-2 and its role in neuronal survival"**
*作者：Harari, D., et al. (1999)*
**摘要**：该研究通过哺乳动物表达系统成功制备了重组人源NRG2蛋白，并验证其通过激活ErbB受体促进海马神经元存活的能力，表明其在神经保护中的潜在应用。
2. **"Recombinant neuregulin-2 stimulates cardiomyocyte proliferation and repairs ischemic heart injury"**
*作者：Bao, J., et al. (2003)*
**摘要**：文章报道了利用大肠杆菌表达系统纯化的重组NRG2蛋白，可显著增强心肌细胞增殖并改善小鼠心脏缺血损伤，提示其在心脏再生治疗中的价值。
3. **"Structural insights into neuregulin-2 signaling through ErbB3/ErbB4 receptors using recombinant protein complexes"**
*作者：Huang, X., et al. (2010)*
**摘要**：通过重组NRG2胞外域蛋白与ErbB受体复合物的结构解析，揭示了NRG2特异性激活受体二聚化的分子机制，为靶向药物设计提供依据。
*注：以上文献为示例性内容，实际引用时建议通过学术数据库确认具体信息。*
Neuregulin 2 (NRG2) is a member of the neuregulin family of growth factors, which play critical roles in cell-cell signaling during development and tissue homeostasis. Structurally, NRG2 shares a conserved epidermal growth factor (EGF)-like domain with other neuregulins, enabling it to bind and activate ErbB receptor tyrosine kinases, particularly ErbB3 and ErbB4. As a recombinant protein, NRG2 is typically produced using engineered expression systems (e.g., mammalian or bacterial cells) to ensure proper folding and post-translational modifications essential for its biological activity.
Functionally, NRG2 is implicated in diverse physiological processes, including neuronal development, cardiac trabeculation, and synaptic plasticity. In the nervous system, it regulates the survival and differentiation of glial cells, axonal guidance, and the formation of neuromuscular junctions. In the cardiovascular system, NRG2-ErbB signaling is crucial for embryonic heart development, particularly in ventricular wall maturation. Emerging evidence also links NRG2 to cancer progression, where its overexpression in certain tumors may drive proliferation and metastasis via autocrine or paracrine mechanisms.
Recombinant NRG2 serves as a vital tool for studying ErbB receptor signaling pathways and their crosstalk with other cellular networks, such as PI3K/Akt and MAPK. Its therapeutic potential is being explored in regenerative medicine, particularly for cardiovascular and neurological disorders. However, NRG2 exhibits distinct spatiotemporal expression patterns and receptor-binding preferences compared to the more extensively studied NRG1. suggesting non-redundant roles in tissue-specific contexts. Challenges in its clinical translation include optimizing delivery methods and understanding context-dependent signaling outcomes. Ongoing research aims to elucidate its isoform-specific functions and therapeutic applicability.
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