| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CLMP |
| Uniprot No | Q9H6B4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 19-233aa |
| 氨基酸序列 | THTEIKRVAEEKVTLPCHHQLGLPEKDTLDIEWLLTDNEGNQKVVITYSS RHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLKPSDEGRYTCKVKNSGR YVWSHVILKVLVRPSKPKCELEGELTEGSDLTLQCESSSGTEPIVYYWQR IREKEGEDERLPPKSRIDYNHPGRVLLQNLTMSYSGLYQCTAGNEAGKES CVVRVTVQYVQSIGMVDHHHHHH |
| 预测分子量 | 25 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CLMP(Cadherin-Like Membrane Protein)重组蛋白的示例参考文献(内容为虚构示例，仅供参考)：
---
1. **文献名称**: *CLMP regulates intestinal epithelial cell adhesion and barrier function*
**作者**: Smith A, et al.
**摘要**: 研究揭示了CLMP重组蛋白在肠道上皮细胞中的功能，证明其通过调控钙黏蛋白介导的细胞间连接维持肠屏障完整性，并发现CLMP缺失导致小鼠模型肠炎易感性增加。
2. **文献名称**: *Recombinant CLMP protein promotes angiogenesis in vitro*
**作者**: Chen L, et al.
**摘要**: 该文献报道了CLMP重组蛋白在血管生成中的作用，通过激活Wnt/β-catenin通路增强内皮细胞迁移和管腔形成，为缺血性疾病治疗提供潜在靶点。
3. **文献名称**: *Structural analysis of CLMP extracellular domain and its role in congenital short bowel syndrome*
**作者**: Müller B, et al.
**摘要**: 通过X射线晶体学解析CLMP胞外域结构，发现其突变与先天性短肠症相关，重组蛋白功能实验证实突变体导致细胞黏附能力下降。
---
**备注**：以上文献为模拟示例，实际研究中请通过PubMed、Web of Science等数据库检索真实文献。CLMP研究多集中于肠道发育、细胞黏附和遗传性疾病领域。
CLMP (CXADR-like membrane protein), also known as ACAM, is a transmembrane protein belonging to the immunoglobulin (Ig) superfamily. It shares structural homology with the Coxsackie and adenovirus receptor (CAR), characterized by extracellular Ig-like domains, a single-pass transmembrane region, and a cytoplasmic tail. Primarily expressed in epithelial and endothelial cells, CLMP plays a critical role in cell-cell adhesion, tissue organization, and morphogenesis. It is notably involved in intestinal development, where it regulates tight junction formation and epithelial barrier integrity. Mutations in the CLMP gene are linked to congenital short bowel syndrome (CSBS), a rare disorder characterized by malabsorption and intestinal dysfunction.
Recombinant CLMP proteins are engineered using expression systems such as mammalian (e.g., HEK293) or insect cells to ensure proper post-translational modifications. These proteins typically include functional domains like the extracellular Ig regions, enabling studies on protein-protein interactions and signaling mechanisms. Researchers utilize recombinant CLMP to investigate its role in cellular adhesion, barrier formation, and pathological conditions. For example, in vitro models demonstrate that CLMP deficiency disrupts epithelial polarity, while animal studies highlight its importance in gut development.
Beyond basic research, recombinant CLMP holds therapeutic potential. It may serve as a biomarker for intestinal disorders or a scaffold for tissue engineering. Additionally, targeting CLMP pathways could inform drug development for CSBS or inflammatory bowel diseases. Ongoing studies also explore its involvement in cancer progression, as altered cell adhesion proteins often influence metastasis. Overall, recombinant CLMP tools are vital for deciphering its biological functions and translational applications in biomedicine.
×
