关键信息
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基因名
IL-4R alpha
- 应用
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别名
Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124
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种属
Canine
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by reducing SDS-PAGE.
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蛋白编号
XP_022275636.1
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表达区间
G2-Q230
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氨基酸序列
GRLCSGLTFPVSCLVLVWVASSGSVKVLHEPSCFSDYISTSVCQWKMDHPTNCSAELRLSYQLDFMGSENHTCVPENREDSVCVCSMPIDDAVEADVYQLDLWAGQQLLWSGSFQPSKHVKPRTPGNLTVHPNISHTWLLMWTNPYPTENHLHSELTYMVNVSNDNDPEDFKVYNVTYMGPTLRLAASTLKSGASYSARVRAWAQTYNSTWSDWSPSTTWLNYYEPWEQ
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蛋白长度
Partial
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分子量
40-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Interleukin-4 receptor alpha (IL-4Rα) is a crucial component of the immune response, mediating effects of the cytokines IL-4 and IL-13, which are key players in allergy and asthma development. Overactivation of the IL-4Rα pathway can lead to exaggerated allergic reactions, making it a potential therapeutic target for allergic diseases and asthma. Recombinant IL-4Rα protein studies are aimed at understanding the receptor's structure, function, and signaling mechanisms, which can provide insights into how IL-4 and IL-13 influence immune responses. By developing and characterizing IL-4Rα recombinant proteins, researchers aim to elucidate its role in T-helper cell differentiation and regulation of immune responses. Furthermore, these proteins can serve as tools for drug discovery and the development of monoclonal antibodies that inhibit IL-4Rα signaling, offering new strategies for treating allergic conditions. Overall, investigating IL-4Rα through recombinant technology holds promise for advancing our understanding of immune regulation and identifying novel therapeutic approaches for immune-mediated diseases.
