| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ATRN |
| Uniprot No | O75882 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1429aa |
| 氨基酸序列 | MVAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAVSGSAAAEAKECDRPCVNGGRCNPGTGQCVCPAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATECSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAAYNLTGFNITYSFDMCPNNCSGRGECKISNSSDTVECECSENWKGEACDIPHCTDNCGFPHRGICNSSDVRGCSCFSDWQGPGCSVPVPANQSFWTREEYSNLKLPRASHKAVVNGNIMWVVGGYMFNHSDYNMVLAYDLASREWLPLNRSVNNVVVRYGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAVVGHSAHIVTLKNGRVVMLVIFGHCPLYGYISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILKDSRFFRYLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVNRFGHSAVLHNSTMYVFGGFNSLLLSDILVFTSEQCDAHRSEAACLAAGPGIRCVWNTGSSQCISWALATDEQEEKLKSECFSKRTLDHDRCDQHTDCYSCTANTNDCHWCNDHCVPRNHSCSEGQISIFRYENCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQECIALPENICGIGWHLVGNSCLKITTAKENYDNAKLFCRNHNALLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPWVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSTRGLKAATCINPLNGSVCERPANHSAKQCRTPCALRTACGDCTSGSSECMWCSNMKQCVDSNAYVASFPFGQCMEWYTMSTCPPENCSGYCTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSQAPTGNFYPQPLLNSSMCLEDSRYNWSFIHCPACQCNGHSKCINQSICEKCENLTTGKHCETCISGFYGDPTNGGKCQPCKCNGHASLCNTNTGKCFCTTKGVKGDECQLCEVENRYQGNPLRGTCYYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASKNFNLNITWAASFSAGTQAGEEMPVVSKTNIKEYKDSFSNEKFDFRNHPNITFFVYVSNFTWPIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREMQQMASRPFASVNVALETDEEPPDLIGGSIKTVPKPIALEPCFGNKAAVLSVFVRLPRGLGGIPPPGQSGLAVASALVDISQQMPIVYKEKSGAVRNRKQQPPAQPGTCI |
| 预测分子量 | 158,5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于ATRN(Attractin)重组蛋白的模拟参考文献示例，供参考：
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1. **标题**: "Expression and Functional Characterization of Recombinant Attractin in Immune Cell Adhesion"
**作者**: Smith J, et al.
**摘要**: 本研究通过哺乳动物表达系统成功表达并纯化重组ATRN蛋白，证实其促进T细胞与内皮细胞的黏附作用，揭示了其在炎症反应中的潜在调控机制。
2. **标题**: "Recombinant ATRN Protein Ameliorates Metabolic Dysfunction in Obese Mouse Models"
**作者**: Chen L, et al.
**摘要**: 利用大肠杆菌系统表达重组ATRN蛋白，并通过动物实验证明其可通过调节瘦素信号通路改善肥胖小鼠的糖代谢异常，为代谢疾病治疗提供新思路。
3. **标题**: "Structural Analysis of ATRN-MCT1 Interaction Using Recombinant Protein Technology"
**作者**: Tanaka K, et al.
**摘要**: 通过体外表达重组ATRN及其突变体，结合X射线晶体学解析了其与单羧酸转运蛋白(MCT1)的互作结构域，阐明了能量代谢中的分子机制。
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**说明**：以上内容为模拟生成，实际文献需通过PubMed、Web of Science等学术数据库检索关键词(如“recombinant Attractin protein”或“ATRN expression”)获取。部分相关研究可能涉及神经退行性疾病、代谢调控或免疫调节领域。
**Background of ATRN Recombinant Protein**
Attractin (ATRN), a member of the membrane-associated transmembrane protein family (MATS), is a multifunctional protein implicated in immune regulation, neurodevelopment, and metabolic processes. Initially identified for its role in chemotaxis and immune cell interactions, ATRN exists in both membrane-bound and secreted isoforms. The recombinant ATRN protein is generated through genetic engineering, typically expressed in mammalian or bacterial systems, to produce a purified, soluble form for experimental and therapeutic applications.
Biologically, ATRN interacts with ligands such as Mahogunin (MGRN1) and participates in signaling pathways regulating inflammation, melanogenesis, and neuronal survival. Studies link ATRN dysfunction to neuroinflammatory disorders, pigmentary abnormalities, and neurodegenerative conditions like Alzheimer’s disease. Its extracellular domains facilitate cell adhesion and receptor-ligand interactions, while intracellular regions may mediate signal transduction.
Recombinant ATRN is widely utilized in research to study immune responses, neuronal repair mechanisms, and metabolic regulation. It also serves as a tool for screening therapeutic agents targeting diseases like multiple sclerosis or obesity. Structurally, the recombinant protein often includes tags (e.g., His-tag) for purification and tracking. Recent advances in protein engineering aim to enhance its stability and bioactivity for clinical translation.
In summary, ATRN recombinant protein provides a critical resource for dissecting its biological roles and advancing treatments for immune and neurological disorders.
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