关键信息
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基因名
uPAR
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简介
The uPAR protein is a receptor for urokinase plasminogen activator and actively localizes and promotes plasmin formation. It mediates proteolysis-independent signaling activated by U-PA and undergoes negative feedback regulation. FITC-Labeled uPAR Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled uPAR protein, expressed by HEK293 , with His labeled tag.
- 应用
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别名
uPAR; PLAUR; CD87; MO3
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种属
Human
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表达系统
HEK293
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标签
His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q03405
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表达区间
L23-R303
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蛋白长度
Partial
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分子量
45-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
uPAR, or the Urokinase Plasminogen Activator Receptor, is a cell surface receptor that plays a crucial role in various physiological and pathological processes, including cell migration, proliferation, and tissue remodeling. It is primarily involved in the plasminogen activation pathway, linking the fibrinolytic system with cellular signaling cascades. Research has shown that uPAR is overexpressed in several types of cancers, contributing to tumor progression, metastasis, and poor prognosis. Given its significant role in tumor biology, uPAR has emerged as a promising target for therapeutic interventions. The development of recombinant uPAR proteins serves as a critical tool for investigating its functional mechanisms and developing uPAR-targeted therapies. These recombinant proteins can be used in various applications, including drug screening, antibody generation, and as potential biomarkers for disease progression. Understanding the structure and function of uPAR through recombinant techniques can also provide insights into designing inhibitors that disrupt its interaction with ligands, thus potentially reducing cancer metastasis and improving treatment outcomes. The ongoing research around uPAR and its recombinant forms is crucial for advancing our knowledge of tumor biology and developing innovative therapeutic strategies.
